Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae

被引：66

作者：

Li, Erwei ^{[2
]}

Tian, Renrong ^{[3
]}

Liu, Shuchun ^{[2
]}

Chen, Xulin ^{[1
,3
]}

Guo, Liangdong ^{[2
]}

Che, Yongsheng ^{[2
]}

机构：

[1] Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, Ctr Bioenergy & Ind Biotechnol, Inst Microbiol, Beijing 100080, Peoples R China

[3] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 04期

关键词：

D O I：

10.1021/np700744t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Pestalotheols A-D (1-4), four new metabolites, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis theae. The structures of these compounds were determined by NMR spectroscopy, and 1 is further confirmed by X-ray crystallography. The absolute configurations of compounds 1 and 3 were assigned by application of the modified Mosher method. Pestalotheol C (3) displayed an inhibitory effect on HIV-1(LAI) replication in C8166 cells with an EC50 value of 16.1 mu M.

引用

页码：664 / 668

页数：5

共 28 条

[1] Phomadecalins A-D and phomapentenone A:: New bioactive metabolites from Phoma sp NRRL 25697, a fungal colonist of Hypoxylon stromata [J].

Che, YS ;

Gloer, JB ;

Wicklow, DT .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (03) :399-402

[2] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].

DALE, JA ;

MOSHER, HS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (02) :512-519

[3] Caryophyllene sesquiterpenoids from a fungicolous isolate of Pestalotiopsis disseminata [J].

Deyrup, ST ;

Swenson, DC ;

Gloer, JB ;

Donald, TW .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (04) :608-611

[4] PRENYLATED C-6 C-3 COMPOUNDS FROM ILLICIUM-TASHIROI [J].

FUKUYAMA, Y ;

SHIDA, N ;

HATA, Y ;

KODAMA, M .

PHYTOCHEMISTRY, 1994, 36 (06) :1497-1503

[5] Phylogenetic significance of morphological characters in the taxonomy of Pestalotiopsis species [J].

Jeewon, R ;

Liew, ECY ;

Simpson, JA ;

Hodgkiss, IJ ;

Hyde, KD .

MOLECULAR PHYLOGENETICS AND EVOLUTION, 2003, 27 (03) :372-383

[6] Pesthetoxin, a new phytotoxin produced by the gray blight fungus, Pestalotiopsis theae [J].

Kimura, Y ;

Kouge, A ;

Nakamura, K ;

Koshino, H ;

Uzawa, J ;

Fujioka, S ;

Kawano, T .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1998, 62 (08) :1624-1626

[7] Prenylated C6-C3 compounds from root bark of Illicium anisatum [J].

Kouno, I ;

Shimamoto, S ;

Jiang, ZH ;

Tanaka, T .

PHYTOCHEMISTRY, 1997, 46 (08) :1389-1392

[8] Torreyanic acid: A selectively cytotoxic quinone dimer from the endophytic fungus Pestalotiopsis microspora [J].

Lee, JC ;

Strobel, GA ;

Lobkovsky, E ;

Clardy, J .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (10) :3232-3233

[9] Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp. [J].

Li, JY ;

Harper, JK ;

Grant, DM ;

Tombe, BO ;

Bashyal, B ;

Hess, WM ;

Strobel, GA .

PHYTOCHEMISTRY, 2001, 56 (05) :463-468

[10] Jesterone and hydroxy-jesterone antioomycete cyclohexenone epoxides from the endophytic fungus Pestalotiopsis jesteri [J].

Li, JY ;

Strobel, GA .

PHYTOCHEMISTRY, 2001, 57 (02) :261-265

← 1 2 3 →