Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography

被引：49

作者：

Gao, Simon S. ^{[1
,2
]}

Xia, Anping ^{[1
]}

Yuan, Tao ^{[3
]}

Raphael, Patrick D. ^{[1
]}

Shelton, Ryan L. ^{[4
]}

Applegate, Brian E. ^{[4
]}

Oghalai, John S. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA

[2] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[3] Baylor Coll Med, Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 USA

[4] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

来源：

OPTICS EXPRESS | 2011年 / 19卷 / 16期

关键词：

TECTORIAL MEMBRANE; CONTINUUM GENERATION; INNER-EAR; VISUALIZATION;

D O I：

10.1364/OE.19.015415

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Human hearing loss often occurs as a result of damage or malformations to the functional soft tissues within the cochlea, but these changes are not appreciable with current medical imaging modalities. We sought to determine whether optical coherence tomography (OCT) could assess the soft tissue structures relevant to hearing using mouse models. We imaged excised cochleae with an altered tectorial membrane and during normal development. The soft tissue structures and expected anatomical variations were visible using OCT, and quantitative measurements confirmed the ability to detect critical changes relevant to hearing. (C) 2011 Optical Society of America

引用

页码：15415 / 15428

页数：14

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