Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis

被引：62

作者：

Mahmud, Shawn A.

Binstadt, Bryce A. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pediat, Div Pediat Rheumatol, Minneapolis, MN 55455 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 9卷

关键词：

autoantibodies; juvenile idiopathic arthritis; antinuclear antibodies; rheumatoid factor; citrullinated self-antigens; anti-citrullinated protein antibodies; carbamylated self-antigens; anti-carbamylated protein antibodies; CYCLIC CITRULLINATED PEPTIDE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CIRCULATING IMMUNE-COMPLEXES; STRESS-PROTEIN BIP; MEMORY B-CELLS; RHEUMATOID-ARTHRITIS; ANTINUCLEAR ANTIBODIES; T-CELLS; ALPHA-ENOLASE; ANTI-CCP;

D O I：

10.3389/fimmu.2018.03168

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoantibody production occurs in juvenile idiopathic arthritis (JIA) and numerous other autoimmune diseases. In some conditions, the autoantibodies are clearly pathogenic, whereas in others the roles are less defined. Here we review various autoantibodies associated with JIA, with a particular focus on antinuclear antibodies and antibodies recognizing citrullinated self-antigens. We explore potential mechanisms that lead to the development of autoantibodies and the use of autoantibody testing in diagnosis and prognosis. Finally, we compare and contrast JIA-associated autoantibodies with those found in adults with rheumatoid arthritis (RA).

引用

页数：10

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