Galectins in Chagas Disease: A Missing Link Between Trypanosoma cruzi Infection, Inflammation, and Tissue Damage

被引：6
作者：
Poncini, Carolina V. [1 ,2 ]
Benatar, Alejandro F. [3 ]
Gomez, Karina A. [4 ]
Rabinovich, Gabriel A. [5 ,6 ]
机构：
[1] Univ Buenos Aires, Consejo Nacl Invest Cient & Tecn, Lab Inmunol Celular & Inmunopatol Infecc, Inst Invest Microbiol & Parasitol Med, Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Inmunol, Buenos Aires, DF, Argentina
[3] Consejo Nacl Invest Cient & Tecn CONICET, Serv Citometr Flujo, Inst Med Expt IMEX, Acad Nacl Med, Buenos Aires, DF, Argentina
[4] Consejo Nacl Invest Cient & Tecn, Lab Biol & Inmunol Infecc Tripanosomatidos, Inst Invest Ingn Genet & Biol Mol, Buenos Aires, DF, Argentina
[5] Consejo Nacl Invest Cient & Tecn, Lab Glicomed, Inst Biol & Med Expt, Buenos Aires, DF, Argentina
[6] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Buenos Aires, DF, Argentina
来源：
FRONTIERS IN MICROBIOLOGY | 2022年 / 12卷
关键词：
galectin; Trypanosoma cruzi; galectin-1; galectin-3; Chagas disease; DENDRITIC CELLS; HOST-CELL; ANTI-GALECTIN-1; AUTOANTIBODIES; GLYCAN INTERACTIONS; IMMUNE-RESPONSES; REGULATED EXPRESSION; UP-REGULATION; T-CELLS; B-CELLS; MYOCARDITIS;
D O I：
10.3389/fmicb.2021.794765
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Trypanosoma cruzi, the protozoan parasite causative agent of Chagas disease, affects about seven million people worldwide, representing a major global public health concern with relevant socioeconomic consequences, particularly in developing countries. In this review, we discuss the multiple roles of galectins, a family of beta-galactoside-binding proteins, in modulating both T. cruzi infection and immunoregulation. Specifically, we focus on galectin-driven circuits that link parasite invasion and inflammation and reprogram innate and adaptive immune responses. Understanding the dynamics of galectins and their beta-galactoside-specific ligands during the pathogenesis of T. cruzi infection and elucidating their roles in immunoregulation, inflammation, and tissue damage offer new rational opportunities for treating this devastating neglected disease.
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页数：13
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