MiR-378a-3p enhances adipogenesis by targeting mitogen-activated protein kinase 1

被引：42

作者：

Huang, Nunu ^{[1
,2
]}

Wang, Jiu ^{[2
]}

Xie, Weidong ^{[2
]}

Lyu, Qing ^{[1
,2
]}

Wu, Jiangbin ^{[1
,2
]}

He, Jie ^{[2
]}

Qiu, Wei ^{[1
,2
]}

Xu, Naihan ^{[2
]}

Zhang, Yaou ^{[2
]}

机构：

[1] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Key Lab Hlth Sci & Technol, Shenzhen 518055, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 457卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Adipogenesis; MiR-378a-3p; MAPK1; GENE-EXPRESSION; RECEPTOR-GAMMA; MAP KINASE; MICRORNAS; DIFFERENTIATION; CELLS; FIBROBLASTS; ADIPOCYTES; METABOLISM; MECHANISM;

D O I：

10.1016/j.bbrc.2014.12.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies showed that miR-378a plays important roles in adipogenesis and obesity; however, the precise mechanisms of action remain unknown. Here, we found that miR-378a-3p expression is up-regulated in adipose tissues of high fat diet-induced obese mice, as well as during the differentiation of 3T3-L1 preadipocytes. Mir-378a-3p induced adipogenesis by targeting mitogen-activated protein kinase 1 (MAPK1). Overexpression of miR-378a-3p or silencing MAPK1 reduced MAPK1 expression and enhanced adipogenesis, whereas blockage of endogenous miR-378a-3p had the opposite effect, suggesting that miR-378a-3p promotes the adipogenesis of 3T3-L1 cells by targeting MAPK1. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：37 / 42

页数：6

共 50 条

[1] Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
Bassi, Rekha
Burgoyne, Joseph R.
DeNicola, Gian F.
Rudyk, Olena
DeSantis, Vittorio
Charles, Rebecca L.
Eaton, Philip
Marber, Michael S.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (39) : 16161 - 16173
[2] Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis
Engelman, JA
Lisanti, MP
Scherer, PE
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (48) : 32111 - 32120
[3] MiR-378 Controls Cardiac Hypertrophy by Combined Repression of Mitogen-Activated Protein Kinase Pathway Factors
Ganesan, Jayavarshni
Ramanujam, Deepak
Sassi, Yassine
Ahles, Andrea
Jentzsch, Claudia
Werfel, Stanislas
Leierseder, Simon
Loyer, Xavier
Giacca, Mauro
Zentilin, Lorena
Thum, Thomas
Laggerbauer, Bernhard
Engelhardt, Stefan
CIRCULATION, 2013, 127 (21) : 2097 - U88
[4] Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors
Austin Duffy
Shivaani Kummar
Targeted Oncology, 2009, 4 : 267 - 273
[5] Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors
Duffy, Austin
Kummar, Shivaani
TARGETED ONCOLOGY, 2009, 4 (04) : 267 - 273
[6] Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1
Fu, Chang-Ning
Song, Jia-Wen
Song, Zhi-Peng
Wang, Qian-Wen
Bai, Wen-Wu
Guo, Tao
Li, Peng
Liu, Chao
Wang, Shuang-Xi
Dong, Bo
AGING-US, 2021, 13 (08): : 11470 - 11490
[7] Targeting mitogen-activated protein kinase in acute ischaemic stroke
Liu, Q.
Gonzales, R. J.
ACTA PHYSIOLOGICA, 2017, 219 (04) : 712 - 714
[8] Targeting the mitogen-activated protein kinase cascade to treat cancer
Sebolt-Leopold, JS
Herrera, R
NATURE REVIEWS CANCER, 2004, 4 (12) : 937 - 947
[9] Targeting the RAS pathway by mitogen-activated protein kinase inhibitors
Kiessling, Michael K.
Rogler, Gerhard
SWISS MEDICAL WEEKLY, 2015, 145
[10] Targeting the mitogen-activated protein kinase cascade to treat cancer
Judith S. Sebolt-Leopold
Roman Herrera
Nature Reviews Cancer, 2004, 4 : 937 - 947

← 1 2 3 4 5 →