Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production

被引：19

作者：

Liang, Shuang ^{[1
,2
]}

Tian, Jun-Mian ^{[3
]}

Feng, Yi ^{[2
]}

Liu, Xiao-Hua ^{[3
]}

Xiong, Zhi ^{[2
]}

Zhang, Wei-Dong ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Engn Res Ctr Modern Preparat Technol TCM, Minist Educ, Shanghai 201203, Peoples R China

[3] Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 05期

关键词：

Daphne aurantiaca; flavonoid; RAW; 264.7; macrophage; nitric oxide; FEDDEI; ODORA; BIFLAVONOIDS; ROOT;

D O I：

10.1248/cpb.59.653

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical examination of the methanolic extract from the stem bark of Daphne aurantiaca led to the isolation of three new flavonoids (1-3), and 29 known flavonoids. All 32 compounds were isolated for the first time from Daphne aurantiaca. The isolates were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 21 and 24 showed potent inhibitory activities against the production of NO with IC50 values of 0.006 and 0.076 mu M, respectively.

引用

页码：653 / 656

页数：4

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