Expression of thyrotropin receptors in rat thymus

被引：18

作者：

Murakami, M ^{[1
]}

Hosoi, Y ^{[1
]}

Araki, O ^{[1
]}

Morimura, T ^{[1
]}

Imamura, M ^{[1
]}

Ogiwara, T ^{[1
]}

Mizuma, H ^{[1
]}

Mori, M ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Dept Internal Med 1, Maebashi, Gumma 3718511, Japan

来源：

LIFE SCIENCES | 2001年 / 68卷 / 25期

关键词：

thymic epithelial cell; cyclic AMP; Graves' disease;

D O I：

10.1016/S0024-3205(01)01077-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Thymic hyperplasia is associated with Graves' disease. It has been demonstrated that thyrotropin receptors are expressed in human thymus, and thymic thyrotropin receptors are suggested to be involved in the pathophysiology of Graves' disease. We have studied whether thyrotropin receptors are expressed in rat thymic tissue. Thyrotropin receptor mRNA was demonstrated in 5-day-old, 10-day-old, 20-day-old and adult rat thymus by reverse transcription polymerase chain reaction. Thyrotropin receptor mRNA was also demonstrated in cultured rat thymic epithelial cells. Thyrotropin stimulated cyclic AMP production in cultured rat thymic epithelial cells, suggesting l:he expression of functional thyrotropin receptors. The present results indicate that thyrotropin receptors are expressed in rat thymus. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：2781 / 2787

页数：7

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