Molecular and Cellular Mechanisms of Vascular Development in Zebrafish

被引:7
作者
Eberlein, Jean [1 ]
Herdt, Lukas [1 ]
Malchow, Julian [1 ]
Rittershaus, Annegret [1 ]
Baumeister, Stefan [1 ]
Helker, Christian S. M. [1 ]
机构
[1] Philipps Univ Marburg, Fac Biol, Cell Signaling & Dynam, D-35043 Marburg, Germany
来源
LIFE-BASEL | 2021年 / 11卷 / 10期
关键词
zebrafish; vasculogenesis; angiogenesis; blood vessels; endothelial cells; signaling pathways; Vegf; Apelin; REGULATES HEMATOPOIETIC STEM; BLOOD-BRAIN-BARRIER; GROWTH-FACTOR VEGF; HEMOGENIC ENDOTHELIUM; LUMEN FORMATION; SPROUTING ANGIOGENESIS; TRANSCRIPTION FACTOR; NEGATIVE REGULATOR; AORTIC ENDOTHELIUM; VESSEL FUSION;
D O I
10.3390/life11101088
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide. However, we are just beginning to understand which signaling pathways guide blood vessel growth in different tissues and organs. The advantages of the model organism zebrafish (Danio rerio) helped to identify novel cellular and molecular mechanisms of vascular growth. In this review we will discuss the current knowledge of vasculogenesis and angiogenesis in the zebrafish embryo. In particular, we describe the molecular mechanisms that contribute to the formation of blood vessels in different vascular beds within the embryo.
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页数:17
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