Joint Application of Lactobacillus plantarum and Bacillus subtilis Improves Growth Performance, Immune Function and Intestinal Integrity in Weaned Piglets

被引：11

作者：

Liu, Yisi ^{[1
]}

Gu, Wei ^{[2
]}

Liu, Xiaoyi ^{[1
]}

Zou, Youwei ^{[1
]}

Wu, Yujun ^{[1
]}

Xu, Youhan ^{[1
]}

Han, Dandan ^{[1
]}

Wang, Junjun ^{[1
]}

Zhao, Jinbiao ^{[1
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

[2] Shandong Baolai Leelai Bioengn Co Ltd, Shandong Prov Key Lab Anim Microecol Agent, Tai An 271000, Peoples R China

来源：

VETERINARY SCIENCES | 2022年 / 9卷 / 12期

基金：

中国国家自然科学基金;

关键词：

probiotics; weaned piglets; immune; intestinal health; gut microbiota; RESISTANCE; MICROBIOTA; CONSEQUENCES; ANTIBIOTICS; PROBIOTICS; PEPTIDES; DIARRHEA; HEALTH; HOST;

D O I：

10.3390/vetsci9120668

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

This study was conducted to explore the effects of the joint application of Lactobacillus plantarum and Bacillus subtilis on growth performance, immune function, antioxidant capacity, intestinal integrity, and gut microbiota composition in weaned piglets. The piglets were allocated randomly into 4 dietary groups, which were a control diet (NC), NC + 150 ppm mucilage sulfate (PC), and 3 additional diets containing 1 kg/t (LT), 1.5 kg/t (MT), or 2 kg/t (HT) mixture of Lactobacillus plantarum and Bacillus subtilis, respectively. Results showed that joint application of Lactobacillus plantarum and Bacillus subtilis increased ADFI and ADG of weaned piglets in d 14 similar to 28 and d 28 similar to 42 (p < 0.05), and decreased serum concentrations of DAO, IL-1 beta, TNF-alpha, and IL-2. The LT group increased jejunal and colonic sIgA contents compared with the PC group (p < 0.05). Groups of MT and HT increased colonic mRNA expression of host defense peptides and tight junction proteins compared with the NC and PC groups. The joint application of Lactobacillus plantarum and Bacillus subtilis increased the abundance of colonic Lactobacillus compared with NC and PC groups (p < 0.10). In conclusion, the joint application of Lactobacillus plantarum and Bacillus subtilis as an antibiotics alternative improved growth performance via promoting immune function and intestinal integrity of weaned piglets.

引用

页数：15

共 37 条

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