Hepatitis B virus genotypes

被引：280
作者：
Kramvis, A
Kew, M
François, G
机构：
[1] Univ Witwatersrand, Sch Med, Dept Med, MRC,Univ Mol Hepatol Res Unit, ZA-2193 Johannesburg, South Africa
[2] Univ Antwerp, Dept Epidemiol & Social Med, WHO, Collaborating Ctr Prevent & Control Viral Hepatit, B-2610 Antwerp, Belgium
来源：
VACCINE | 2005年 / 23卷 / 19期
关键词：
subgenotypes; serotypes; recombination;
D O I：
10.1016/j.vaccine.2004.10.045
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Eight genotypes of hepatitis B virus (A-H) are currently recognized, and subgenotypes have recently been described in four of these genotypes (A, B, C and F). The genotypes show a distinct geographical distribution between and even within regions, and are proving to be an invaluable tool in tracing the molecular evolution and patterns and modes of spread of hepatitis B virus. Structural and functional differences between genotypes can influence the severity, course and likelihood of complications, and response to treatment of hepatitis B virus infection and possibly vaccination against the virus. Although the number of studies on these genotypes has increased dramatically during recent years, much remains to be learnt about their full implications. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2409 / 2423
页数：15
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