Detection and Characterization of Antibiotic-Resistant Bacteria Using Surface-Enhanced Raman Spectroscopy

被引:84
作者
Wang, Kaidi [1 ]
Li, Shenmiao [1 ]
Petersen, Marlen [1 ]
Wang, Shuo [2 ]
Lu, Xiaonan [1 ]
机构
[1] Univ British Columbia, Fac Land & Food Syst, Food Nutr & Hlth Program, Vancouver, BC V6T 1Z4, Canada
[2] Nankai Univ, Sch Med, Tianjin Key Lab Food Sci & Hlth, Tianjin 300371, Peoples R China
基金
加拿大自然科学与工程研究理事会;
关键词
SERS; chemometrics; resistance; biosensing; rapid detection; LABEL-FREE IDENTIFICATION; PLASMONIC HOT-SPOTS; SERS DETECTION; SINGLE-MOLECULE; MAGNETIC NANOPARTICLES; SALMONELLA-TYPHIMURIUM; PATHOGENIC BACTERIA; SENSITIVE DETECTION; MASS-SPECTROMETRY; SCATTERING SERS;
D O I
10.3390/nano8100762
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This mini-review summarizes the most recent progress concerning the use of surface enhanced Raman spectroscopy (SERS) for the detection and characterization of antibiotic-resistant bacteria. We first discussed the design and synthesis of various types of nanomaterials that can be used as the SERS-active substrates for biosensing trace levels of antibiotic-resistant bacteria. We then reviewed the tandem-SERS strategy of integrating a separation element/platform with SERS sensing to achieve the detection of antibiotic-resistant bacteria in the environmental, agri-food, and clinical samples. Finally, we demonstrated the application of using SERS to investigate bacterial antibiotic resistance and susceptibility as well as the working mechanism of antibiotics based on spectral fingerprinting of the whole cells.
引用
收藏
页数:21
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