Iridium-SYNPHOS-Catalyzed Hydrogenation through Dynamic Kinetic Resolution of α-Amino β-Keto Ester Hydrochlorides

被引：11

作者：

Echeverria, Pierre-Georges ^{[1
]}

Ferard, Charlene ^{[1
]}

Cornil, Johan ^{[2
]}

Guerinot, Amandine ^{[2
]}

Cossy, Janine ^{[2
]}

Phansavath, Phannarath ^{[1
]}

Ratovelomanana-Vidal, Virginie ^{[1
]}

机构：

[1] PSL Res Univ, CNRS, Inst Rech Chim Paris, Chim ParisTech, F-75005 Paris, France

[2] PSL Res Univ, ESPCI ParisTech, Inst Chem Biol & Innovat CBI, CNRS,UMR 8231,Lab Chim Organ, F-75231 Paris 05, France

来源：

SYNLETT | 2014年 / 25卷 / 19期

关键词：

iridium; hydrogenation; asymmetric catalysis; enantioselectivity; amino alcohols; SELECTIVE ASYMMETRIC HYDROGENATION; STEREOSELECTIVE-SYNTHESIS; DIPHOSPHINE LIGAND; EFFICIENT ROUTE; HYDROXY ESTERS; ACID-ESTERS; DIFLUORPHOS; COMPLEXES;

D O I：

10.1055/s-0034-1379232

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis of anti -hydroxy -amino esters by iridium-SYNPHOS-catalyzed asymmetric hydrogenation of -amino -keto ester hydrochlorides is reported. The reaction proceeded through dynamic kinetic resolution to afford a variety of -hydroxy -amino ester derivatives with good yields and high level of diastereo- and enantioselectivities (de up to 99%, ee up to 92%).

引用

页码：2761 / 2764

页数：4

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