Peripheral blood stem cell collection and transplantation using the Haemonetics Multi Component System

被引：3

作者：

Kishi, S ^{[1
]}

Wano, Y ^{[1
]}

Misaki, H ^{[1
]}

Imamura, S ^{[1
]}

Kawai, Y ^{[1
]}

Nakayama, T ^{[1
]}

Fukushima, T ^{[1
]}

Tsutani, H ^{[1
]}

Ueda, T ^{[1
]}

机构：

[1] Fukui Med Univ, Dept Internal Med 1, Fukui 9101193, Japan

来源：

TRANSFUSION SCIENCE | 1999年 / 20卷 / 01期

关键词：

D O I：

10.1016/S0955-3886(98)00087-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To assess clinical usefulness of an intermittent-flow blood cell separator in peripheral blood stem cell (PBSC) collection and transplantation. Results: the Haemonetics Multi Component System (Multi) was used to collect PBSC (52 aphereses in 17 patients). The mean processing blood volume and the mean PBSC yield were 7407 ml and 2.16 x 10(6) kCD34(+) cells/kg, respectively. When CD34+ cells exceeded 0.3% of the peripheral WBC, more than 2.0 x 10(6) CD34+ cells/kg could be collected by a single apheresis. Eight patients underwent PBSC transplantation after high-dose chemotherapy. Hematopoietic recovery was achieved in a median period of 10 days. Conclusions: (1) A single-arm, light-weight machine has sufficient capability to collect PBSC. (2) The percentage of CD34+ cells in the peripheral WBC is a good predictor of the CD34+ cell yield of the collection. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：21 / 27

页数：7

共 16 条

[1] Bender J G, 1992, J Hematother, V1, P329, DOI 10.1089/scd.1.1992.1.329
[2] PERIPHERAL-BLOOD STEM-CELLS (PBSCS) COLLECTED AFTER RECOMBINANT GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) - AN ANALYSIS OF FACTORS CORRELATING WITH THE TEMPO OF ENGRAFTMENT AFTER TRANSPLANTATION
BENSINGER, WI
LONGIN, K
APPELBAUM, F
ROWLEY, S
WEAVER, C
LILLEBY, K
GOOLEY, T
LYNCH, M
HIGANO, T
KLARNET, J
CHAUNCEY, T
STORB, R
BUCKNER, CD
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1994, 87 (04) : 825 - 831
[3] BERNSTEIN ID, 1991, BLOOD, V77, P2316
[4] FAUSER AA, 1978, BLOOD, V52, P1243
[5] HAAS R, 1994, BLOOD, V83, P3787
[6] KESSINGER A, 1989, BLOOD, V74, P1260
[7] MAKINO S, 1991, BONE MARROW TRANSPL, V8, P239
[8] MEHTA J, 1995, BONE MARROW TRANSPL, V16, P707
[9] NAKAMURA T, 1985, ACTA HAEMATOL JAPON, V48, P734
[10] PERIPHERAL-BLOOD STEM-CELL COLLECTION WITH A BLOOD-CELL SEPARATOR
NOROL, F
SCOTTO, F
DUEDARI, N
BEAUJEAN, F
[J]. TRANSFUSION, 1993, 33 (11) : 894 - 897

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