First synthesis of an amythiamicin pyridine cluster

被引：30

作者：

Bagley, MC

Dale, JW

Jenkins, RL

Bower, J

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3TB, S Glam, Wales

[2] Vernalis, Cambridge CB1 6GB, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 01期

关键词：

D O I：

10.1039/b310944e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pyridine-containing central domain of the amythiamicin group of thiopeptide antibiotics is prepared in protected form in 9 steps, 93% ee and 18% overall yield from (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropylithiazole-4-carboxylic acid by Michael addition-cyclodehydration of a 2-(2-thiazolyl)enamine and 1-(2-thiazolyl)propynone.

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收藏

页码：102 / 103

页数：2

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