Synergistic Effect of Photothermal Therapy and Chemotherapy Using Camptothecin-Conjugated Gold Nanorods

被引：27

作者：

Yang, Soojung ^{[1
]}

Palanikumar, L. ^{[2
]}

Jeong, Sundo ^{[1
]}

Kim, Kibeom ^{[2
]}

Lee, Jungmin ^{[1
]}

Jeoung, Eunhee ^{[3
]}

Kim, Chaekyu ^{[2
]}

Ryu, Ja-Hyoung ^{[2
]}

Park, Myoung-Hwan ^{[1
]}

机构：

[1] Sahmyook Univ, Dept Chem, Seoul 01795, South Korea

[2] Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea

[3] Gangneung Wonju Natl Univ, Dept Chem, Kangnung 25457, South Korea

来源：

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | 2018年 / 35卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

chemotherapy; gold nanorods; light-triggered release; near-IR; photothermal therapy; DRUG-DELIVERY; CANCER-CELLS; TUMOR-CELLS; NANOPARTICLES; NANOCARRIERS; RELEASE; FUTURE; NANOCAGES; TOXICITY;

D O I：

10.1002/ppsc.201700307

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A combinatorial treatment comprising thermal therapy and chemotherapy offers synergistic effects by inducing localized heat to targeted tumor sites and simultaneously delivering anticancer drugs to minimize systemic side effects and enhance the cytotoxic effect. In this study, a novel platform is developed for combining photothermal therapy and chemotherapy using drug-conjugated gold nanorods (GNRs). Camptothecin (CPT), a model anticancer drug, is chemically conjugated onto GNRs through hydrolytic ester bonding. Upon near-infrared (NIR) irradiation, localized heat from GNRs in target areas starts to destroy tissues and cells via photothermal therapy, and the elevated temperature accelerates hydrolysis of ester linkage, rapidly releasing drugs for chemotherapy. This combined NIR triggered thermal therapy and chemotherapy with CPT-functionalized GNRs (CPT-GNRs) presents a synergistic effect that has high efficacy in in vitro tests, thus providing a robust platform for efficient cancer treatments.

引用

页数：9

共 44 条

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