Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam

被引：6

作者：

Barvaliya, Manish ^{[1
]}

Sanmukhani, Jayesh ^{[1
]}

Patel, Tejas K. ^{[1
]}

Tripathi, C. B. ^{[1
]}

机构：

[1] Govt Med Coll, Dept Pharmacol, Bhavnagar 364001, Gujarat, India

来源：

INDIAN JOURNAL OF PHARMACOLOGY | 2011年 / 43卷 / 06期

关键词：

Adverse drug reaction; anti-seizure drugs; chorea; drug interactions; phenytoin; ADVERSE DRUG-REACTIONS;

D O I：

10.4103/0253-7613.89839

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A 3-year-old female patient developed chorea possibly due to an interaction between phenytoin, phenobarbital and clobazam used for generalized tonic clonic seizures. Phenytoin withdrawal resulted in recovery within 24 hours. Post reaction computerized tomography (CT)-scan of brain was normal. Combined use of anti-seizure drugs and interactions between them may be responsible for the reaction. Therapeutic drug monitoring is important while prescribing two or more anti-seizure drugs.

引用

页码：731 / 732

页数：2

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