Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report

被引：79

作者：

Doll, Jessica P. K. ^{[1
]}

Vazquez-Castellanos, Jorge F. ^{[2
]}

Schaub, Anna-Chiara ^{[1
]}

Schweinfurth, Nina ^{[1
]}

Kettelhack, Cedric ^{[1
]}

Schneider, Else ^{[1
]}

Yamanbaeva, Gulnara ^{[1
]}

Mahlmann, Laura ^{[1
]}

Brand, Serge ^{[3
,4
,5
,6
,7
]}

Beglinger, Christoph ^{[8
]}

Borgwardt, Stefan ^{[1
,9
]}

Raes, Jeroen ^{[2
]}

Schmidt, Andre ^{[1
]}

Lang, Undine E. ^{[1
]}

机构：

[1] Univ Basel, Dept Psychiat UPK, Basel, Switzerland

[2] Univ Leuven, Rega Inst Med Res, Dept MicroBiol & Immunol, KU Leuven, Leuven, Belgium

[3] Univ Basel, Ctr Affect Stress & Sleep Disorders ZASS, Psychiat Clin UPK, Basel, Switzerland

[4] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah, Iran

[5] Kermanshah Univ Med Sci, Subst Abuse Prevent Res Ctr, Kermanshah, Iran

[6] Univ Basel, Dept Sport Exercise & Hlth, Div Sport Sci & Psychosocial Hlth, Basel, Switzerland

[7] Univ Tehran Med Sci, Sch Med, Dept Psychiat, Tehran, Iran

[8] St Clara Hosp, Dept Res, Basel, Switzerland

[9] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany

来源：

FRONTIERS IN PSYCHIATRY | 2022年 / 13卷

关键词：

FMT; depression; gastrointestinal; microbiome-gut-brain axis (MGBA); case report; CLOSTRIDIUM-DIFFICILE INFECTION; IRRITABLE-BOWEL-SYNDROME; GUT MICROBIOTA; ANXIETY; BRAIN; METAANALYSIS; PROBIOTICS; RICHNESS; SYMPTOMS; GROWTH;

D O I：

10.3389/fpsyt.2022.815422

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.

引用

页数：9

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