Whole Brain Hemodynamic Response Based on Synchrony Analysis of Brain Signals for Effective Application of HD-tDCS in Stroke Patients: An fNIRS Study

被引：10
作者：
Lee, Gihyoun [1 ,2 ]
Lee, Jungsoo [3 ]
Kim, Jinuk [1 ,2 ]
Kim, Heegoo [1 ,2 ]
Chang, Won Hyuk [2 ]
Kim, Yun-Hee [1 ,2 ,4 ]
机构：
[1] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Hlth Sci & Technol, Seoul 06351, South Korea
[2] Sungkyunkwan Univ, Ctr Prevent & Rehabil, Samsung Med Ctr, Heart Vasc Stroke Inst,Sch Med,Dept Phys & Rehabi, Seoul 06351, South Korea
[3] Kumoh Natl Inst Technol, Dept Med IT Convergence Engn, Gumi 39177, South Korea
[4] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Med Device Management & Res, Dept Digital Hlth, Seoul 06351, South Korea
来源：
JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
hemodynamic response; brain signal synchronization; HD-tDCS; fNIRS; stroke patients; DIRECT-CURRENT STIMULATION; NEAR-INFRARED SPECTROSCOPY; CEREBRAL-BLOOD-FLOW; MOTOR CORTEX; MODULATION; POSITION;
D O I：
10.3390/jpm12030432
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
In this study, the effective application of high-definition transcranial direct current stimulation (HD-tDCS) based on the whole brain hemodynamic response in stroke patients was investigated using functional near-infrared spectroscopy (fNIRS). The intrahemispheric and interhemispheric synchronization and cortical activity based on the time during 1 mA HD-tDCS were examined in 26 chronic cerebrovascular disease patients. At the beginning of HD-tDCS, the synchronization and brain activity in the whole brain increased rapidly and decreased after 5 min. In the middle of tDCS, the synchronization began to increase again, and strong synchronic connections were formed around the desired stimulation area. After tDCS, strong cortical activation was observed in the stimulation area, indicating that the baseline of the oxyhemoglobin (HbO) signal increased in the desired stimulation area. Therefore, the results of this study indicate that HD-tDCS can be applied efficiently to enhance the effect of tDCS. This stimulation method with tDCS can be explored clinically for more neurorehabilitation of patients with degenerative brain diseases.
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页数：13
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