Profiles of immune cell infiltration and their clinical significance in head and neck squamous cell carcinoma

被引：23

作者：

Jin, Yu ^{[2
,3
,4
]}

Qin, Xing ^{[1
,3
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai 200011, Peoples R China

[2] Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Gen Dent, Shanghai 200011, Peoples R China

[3] Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China

[4] Natl Clin Res Ctr Stomatol, Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 82卷

基金：

国家重点研发计划;

关键词：

Tumor-infiltrating immune cells (TIICs); Head and neck squamous cell carcinoma (HNSCC); CIBERSORT; Prognosis; TNM stage; TCGA; DENDRITIC CELLS; T-CELLS; CANCER; MACROPHAGES; MICROENVIRONMENT; LYMPHOCYTES; MONOCYTES; TARGETS;

D O I：

10.1016/j.intimp.2020.106364

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is well established that there exist comprehensive interactions between tumor immunology and tumor biology. Tumor-infiltrating immune cells (TIICs) have been appealing therapeutic targets due to their significance in regulating cancer progression. The purpose of this study was to illustrate the comprehensive landscape of TIICs composition in head and neck squamous cell carcinoma (HNSCC) and their clinical significance. CIBERSORT was applied to calculate the 22 immune cell types proportion in HNSCC and further analysis suggested that six kinds of immune cells (resting memory CD4 T cells, Ml macrophages, resting dendritic cells, resting mast cells, monocytes, and eosinophils) were closely correlated with HNSCC progression. Moreover, memory CD4 T cells may serve as prognosis indicator for HNSCC patients. Collectively, this study uncovered the immune cells infiltration landscape in HNSCC and illustrated their potential relationships with clinical parameters, thereby contributing to the development of customized treatment strategy.

引用

页数：8

共 28 条

[1] Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers [J].

Allaoui, Roni ;

Bergenfelz, Caroline ;

Mohlin, Sofie ;

Hagerling, Catharina ;

Salari, Kiarash ;

Werb, Zena ;

Anderson, Robin L. ;

Ethier, Stephen P. ;

Jirstrom, Karin ;

Pahlman, Sven ;

Bexell, Daniel ;

Tahin, Balazs ;

Johansson, Martin E. ;

Larsson, Christer ;

Leandersson, Karin .

NATURE COMMUNICATIONS, 2016, 7

[2] Treatment of renal cell carcinoma: Current status and future directions [J].

Barata, Pedro C. ;

Rini, Brian I. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (06) :507-524

[3] The Promise of Targeting Macrophages in Cancer Therapy [J].

Brown, J. Martin ;

Recht, Lawrence ;

Strober, Samuel .

CLINICAL CANCER RESEARCH, 2017, 23 (13) :3241-3250

[4]

Chen BB, 2018, METHODS MOL BIOL, V1711, P243, DOI 10.1007/978-1-4939-7493-1_12

[5] Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells [J].

Engelhardt, John J. ;

Boldajipour, Bijan ;

Beemiller, Peter ;

Pandurangi, Priya ;

Sorensen, Caitlin ;

Werb, Zena ;

Egeblad, Mikala ;

Krummel, Matthew F. .

CANCER CELL, 2012, 21 (03) :402-417

[6] Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy [J].

Evrard, Diane ;

Szturz, Petr ;

Tijeras-Raballand, Annemilai ;

Astorgues-Xerri, Lucile ;

Abitbol, Chloe ;

Paradis, Valerie ;

Raymond, Eric ;

Albert, Sebastien ;

Barry, Beatrix ;

Faivre, Sandrine .

ORAL ONCOLOGY, 2019, 88 :29-38

[7] M1 and M2 macrophages' clinicopathological significance in cutaneous melanoma [J].

Falleni, Monica ;

Savi, Federica ;

Tosi, Delfina ;

Agape, Elena ;

Cerri, Amilcare ;

Moneghini, Laura ;

Bulfamante, Gaetano P. .

MELANOMA RESEARCH, 2017, 27 (03) :200-210

[8] Rheostatic Functions of Mast Cells in the Control of Innate and Adaptive Immune Responses [J].

Frossi, Barbara ;

Mion, Francesca ;

Tripodo, Claudio ;

Colombo, Mario P. ;

Pucillo, Carlo E. .

TRENDS IN IMMUNOLOGY, 2017, 38 (09) :648-656

[9] Dendritic Cells and Cancer Immunity [J].

Gardner, Alycia ;

Ruffell, Brian .

TRENDS IN IMMUNOLOGY, 2016, 37 (12) :855-865

[10] Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis [J].

Janco, Jo Marie Tran ;

Lamichhane, Purushottam ;

Karyampudi, Lavakumar ;

Knutson, Keith L. .

JOURNAL OF IMMUNOLOGY, 2015, 194 (07) :2985-2991

← 1 2 3 →