Vaccines to treat opioid use disorders and to reduce opioid overdoses

被引:16
作者
Baehr, Carly [1 ,2 ]
Pravetoni, Marco [2 ,3 ,4 ]
机构
[1] Univ Minnesota, Dept Vet Populat Med, St Paul, MN 55108 USA
[2] Hennepin Healthcare Res Inst, Minneapolis, MN 55404 USA
[3] Univ Minnesota, Dept Med, Ctr Immunol, Box 736 UMHC, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Dept Pharmacol, Ctr Immunol, 3-249 Millard Hall, Minneapolis, MN 55455 USA
关键词
EFFICACY; HAPTEN; DRUGS; ABUSE;
D O I
10.1038/s41386-018-0197-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:217 / 218
页数:2
相关论文
共 7 条
[1]   Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs [J].
Bremer, Paul T. ;
Kimishima, Atsushi ;
Schlosburg, Joel E. ;
Zhou, Bin ;
Collins, Karen C. ;
Janda, Kim D. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (11) :3772-3775
[2]   Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality [J].
Hwang, Candy S. ;
Bremer, Paul T. ;
Wenthur, Cody J. ;
Ho, Sam On ;
Chiang, SuMing ;
Ellis, Beverly ;
Zhou, Bin ;
Fuji, Gary ;
Janda, Kim D. .
MOLECULAR PHARMACEUTICS, 2018, 15 (03) :1062-1072
[3]   Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose [J].
Laudenbach, Megan ;
Baruffaldi, Federico ;
Robinson, Christine ;
Carter, Philipp ;
Seelig, Davis ;
Baehr, Carly ;
Pravetoni, Marco .
SCIENTIFIC REPORTS, 2018, 8
[4]   The Frequency of Naive and Early-Activated Hapten-Specific B Cell Subsets Dictates the Efficacy of a Therapeutic Vaccine against Prescription Opioid Abuse [J].
Laudenbach, Megan ;
Baruffaldi, Federico ;
Vervacke, Jeffrey S. ;
Distefano, Mark D. ;
Titcombe, Philip J. ;
Mueller, Daniel L. ;
Tubo, Noah J. ;
Griffith, Thomas S. ;
Pravetoni, Marco .
JOURNAL OF IMMUNOLOGY, 2015, 194 (12) :5926-5936
[5]   Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse [J].
Raleigh, M. D. ;
Peterson, S. J. ;
Laudenbach, M. ;
Baruffaldi, F. ;
Carroll, F. I. ;
Comer, S. D. ;
Navarro, H. A. ;
Langston, T. L. ;
Runyon, S. P. ;
Winston, S. ;
Pravetoni, M. ;
Pentel, P. R. .
PLOS ONE, 2017, 12 (12)
[6]   Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats [J].
Raleigh, Michael D. ;
Laudenbach, Megan ;
Baruffaldi, Federico ;
Peterson, Samantha J. ;
Roslawski, Michaela J. ;
Birnbaum, Angela K. ;
Carroll, F. Ivy ;
Runyon, Scott P. ;
Winston, Scott ;
Pentel, Paul R. ;
Pravetoni, Marco .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2018, 365 (02) :346-353
[7]   A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse [J].
Sulima, Agnieszka ;
Jalah, Rashmi ;
Antoline, Joshua F. G. ;
Torres, Oscar B. ;
Imler, Gregory H. ;
Deschamps, Jeffrey R. ;
Beck, Zoltan ;
Alving, Carl R. ;
Jacobson, Arthur E. ;
Rice, Kenner C. ;
Matyas, Gary R. .
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (01) :329-343