Atractylenolide II Induces Apoptosis of Prostate Cancer Cells through Regulation of AR and JAK2/STAT3 Signaling Pathways

被引：28

作者：

Wang, Jing ^{[1
,2
]}

Nasser, Moussa Ide ^{[3
,4
]}

Adlat, Salah ^{[3
,4
]}

Jiang, Ming Ming ^{[2
]}

Jiang, Nan ^{[3
,4
]}

Gao, Li ^{[1
]}

机构：

[1] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Heilongjiang, Peoples R China

[2] Heilongjiang Agr Econ Vocat Coll, Coll Anim Sci, Mudanjiang 157041, Heilongjiang, Peoples R China

[3] Dalian Univ, Coll Life Sci, Dalian 116622, Liaoning, Peoples R China

[4] Dalian Univ, Coll Technol, Dalian 116622, Liaoning, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 12期

关键词：

ATR II; JAK2; STAT3; apoptosis; G2; M arrest; AR; PIAS1;

D O I：

10.3390/molecules23123298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostate cancer is the most common illness affecting men worldwide. Although much progress has been made in the study of prostate cancer prevention and treatment, less attention has been paid to the molecular mechanism of the disease. The molecular arrangement by which atractylenolide II (ATR II) induces human prostate cancer cytotoxicity was comprehensively examined in the present study. As indicated by the results, ATR II could inhibit prostate cancer cell proliferation and promote DU145 and LNCaP cell apoptosis through induced G2/M cell cycle arrest. The cell apoptosis process induced by ATR II in both DU145 and LNCaP cells was associated with its ability to inhibit androgen receptor (AR) with overexpression of protein inhibitor of activated STAT-1 (PIAS1) and the repression of Janus kinase (Jak2) signaling pathways. The data from the present study demonstrated the antitumor effects and the potential pharmacological application of ATR II as an efficient drug for prostate cancer treatment.

引用

页数：11

共 16 条

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