Double-edged sword of inflammasome genetics in colorectal cancer prognosis

被引：13
作者：
Goncalves Cambui, Raylane Adrielle [1 ,2 ]
do Espirito Santo, Gilmar Ferreira [3 ]
Fernandes, Fernanda Pereira [2 ]
Cordeiro Leal, Vinicius Nunes [2 ]
Galera, Bianca Borsatto [1 ]
Palacio Favaro, Emerson Giuliano [4 ]
Rizzo, Leonardo Amorim [5 ]
Elias, Rosa Maria [5 ]
Pontillo, Alessandra [2 ]
机构：
[1] Univ Fed Mato Grosso, Fac Med, Cuiaba, MT, Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo, SP, Brazil
[3] Hosp Geral & Maternidade Cuiaba, Inst Tumores & Cuidados Paliat Cuiaba, Cuiaba, MT, Brazil
[4] Univ Cuiaba, Cuiaba, MT, Brazil
[5] Ctr Univ Varzea Grande, Varzea Grande, MT, Brazil
来源：
CLINICAL IMMUNOLOGY | 2020年 / 213卷
基金：
巴西圣保罗研究基金会;
关键词：
Inflammasome; Colorectal cancer; SNPs; NLRP1; NLRP3; IL18; SUSCEPTIBILITY; INTERLEUKIN-18; AUGMENTATION; IMMUNITY; PLATFORM; GENES;
D O I：
10.1016/j.clim.2020.108373
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1 beta and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening. In this study, 215 CRC patients followed-up for 10 years were examined for 9 polymorphisms in selected inflammasome genes. Multivariate association analysis and survival analysis were performed to evaluate the association between the polymorphisms and CRC prognosis. Variants associated with lower levels of IL-18 (rs1834481, rs5744256), or with increased activation of inflammasome receptors NLRP1 (rs12150220) and NLRP3 (rs35829419) resulted detrimental to CRC prognosis and may be used as prognostic markers.
引用
收藏
页数：6
相关论文
共 37 条
  • [1] [Anonymous], [No title captured]
  • [2] [Anonymous], [No title captured]
  • [3] [Anonymous], [No title captured]
  • [4] Haploview: analysis and visualization of LD and haplotype maps
    Barrett, JC
    Fry, B
    Maller, J
    Daly, MJ
    [J]. BIOINFORMATICS, 2005, 21 (02) : 263 - 265
  • [5] The NOD-Like Receptor Signalling Pathway in Helicobacter pylori Infection and Related Gastric Cancer: A Case-Control Study and Gene Expression Analyses (vol 9, e98899, 2014)
    Castano-Rodriguez, N.
    Kaakoush, N. O.
    Goh, K-L
    K M, Fock
    Mitchell, H. M.
    [J]. PLOS ONE, 2015, 10 (01):
  • [6] Genotyping and differential expression analysis of inflammasome genes in sporadic malignant melanoma reveal novel contribution of CARD8, IL1B and IL18 in melanoma susceptibility and progression
    da Silva, Wanessa Cardoso
    Oshiro, Telma Miyuki
    de Sa, Daniel Coelho
    Franco, Dilcilea D. G. S.
    Neto, Cyro Festa
    Pontillo, Alessandra
    [J]. CANCER GENETICS, 2016, 209 (10) : 474 - 480
  • [7] Genetic Predictors of Glucocorticoid Response in Pediatric Patients With Inflammatory Bowel Diseases
    De Iudicibus, Sara
    Stocco, Gabriele
    Martelossi, Stefano
    Londero, Margherita
    Ebner, Egle
    Pontillo, Alessandra
    Lionetti, Paolo
    Barabino, Arrigo
    Bartoli, Fiora
    Ventura, Alessandro
    Decorti, Giuliana
    [J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 2011, 45 (01) : E1 - E7
  • [8] Interleukin-18: a regulator of cancer and autoimmune diseases
    Esmailbeig, Maryam
    Ghaderi, Abbas
    [J]. EUROPEAN CYTOKINE NETWORK, 2017, 28 (04) : 127 - 140
  • [9] TNMF versus TNM in staging of colorectal cancer
    Farag, Ahmed Ahmed Farag
    Elbarmelgi, Mohamed Yehia
    Azim, Hamdy A.
    Abozeid, Ahmed Abdelaziz
    Mashhour, Abdrabou N.
    [J]. INTERNATIONAL JOURNAL OF SURGERY, 2016, 27 : 147 - 150
  • [10] The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
    Franchi, Luigi
    Eigenbrod, Tatjana
    Munoz-Planillo, Raul
    Nunez, Gabriel
    [J]. NATURE IMMUNOLOGY, 2009, 10 (03) : 241 - 247
1234