Immune responses and immunopathology in acute and chronic viral hepatitis

被引：274
作者：
Shin, Eui-Cheol [1 ]
Sung, Pil Soo [1 ,2 ]
Park, Su-Hyung [3 ]
机构：
[1] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Lab Immunol & Infect Dis, Daejeon 34141, South Korea
[2] Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Div Hepatol, Seoul 06591, South Korea
[3] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Lab Translat Immunol & Vaccinol, Daejeon 34141, South Korea
来源：
NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
C VIRUS-INFECTION; CD8(+) T-CELLS; NATURAL-KILLER-CELLS; B-VIRUS; INTERFERON-ALPHA; A VIRUS; NEUTRALIZING ANTIBODIES; SPONTANEOUS CLEARANCE; ANTIVIRAL ACTIVITY; INNATE IMMUNITY;
D O I：
10.1038/nri.2016.69
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible for most cases of viral hepatitis. Infection by each type of virus results in a different typical natural disease course and clinical outcome that are determined by virological and immunological factors. HCV tends to establish a chronic persistent infection, whereas HAV does not. HBV is effectively controlled in adults, although it persists for a lifetime after neonatal infection. In this Review, we discuss the similarities and differences in immune responses to and immunopathogenesis of HAV, HBV and HCV infections, which may explain the distinct courses and outcomes of each hepatitis virus infection.
引用
收藏
页码：509 / 523
页数：15
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