Unravelling hepatitis C virus replication from genome to function

被引：614

作者：

Lindenbach, BD ^{[1
]}

Rice, CM ^{[1
]}

机构：

[1] Rockefeller Univ, Ctr Study Hepatitis C, New York, NY 10021 USA

来源：

NATURE | 2005年 / 436卷 / 7053期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature04077

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to dissect this pathogen has met with roadblocks that impeded progress. Its replication was restricted to humans or experimentally infected chimpanzees, and efficient growth of the virus in cell culture failed until very recently. Nevertheless hard-fought progress has been made and the first wave of antiviral drugs is entering clinical trials.

引用

页码：933 / 938

页数：6

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