New phenolic glycosides from Curculigo orchioides and their xanthine oxidase inhibitory activities

被引：12

作者：

Chen, Xinglong ^{[1
,3
]}

Zuo, Aixue ^{[1
]}

Deng, Zhentao ^{[1
,3
]}

Huang, Xiaoyan ^{[1
,2
]}

Zhang, Xuemei ^{[1
,2
]}

Geng, Changan ^{[1
,2
]}

Li, Tianze ^{[1
,2
]}

Chen, Jijun ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China

[2] Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

FITOTERAPIA | 2017年 / 122卷

关键词：

Phenolic glycosides; Xanthine oxidase inhibitory activity; Curculigo orchioides; PHENYLPROPANOIDS; MEGASTIGMANE; GLUCOSIDES; EXTRACT; SPONGE; LEAVES; GOUT;

D O I：

10.1016/j.fitote.2017.09.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new phenolic glycosides including two heterocyclic phenolic derivatives orcinosides I-J (1-2) and five chlorophenolic glycosides curculigines J-N (3-7), together with nineteen known compounds were isolated from the rhizome of Curculigo orchioides. Based on extensive spectroscopic analyses (UV, IR, HRESIMS, 1D and 2D NMR), the structures of the new compounds were identified. Orcinoside I (1) and J (2) displayed xanthine oxidase inhibitory activities with IC50 values 0.25 and 0.62 mM respectively.

引用

收藏

页码：144 / 149

页数：6

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