Energy Remodeling, Mitochondrial Disorder and Heart Failure

被引：10

作者：

Wang, Peng ^{[1
]}

Xu, Lei ^{[1
]}

Sun, Aijun ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai 200032, Peoples R China

[2] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 31期

关键词：

Energy metabolism; mitochondrial disorder; heart failure; ACTIVATED PROTEIN-KINASE; PRESSURE-OVERLOAD; OXIDATIVE STRESS; FAILING HEART; CYTOCHROME-C; MYOCARDIAL-INFARCTION; CARDIAC-HYPERTROPHY; THERAPEUTIC TARGET; EXERCISE CAPACITY; METABOLIC THERAPY;

D O I：

10.2174/1381612822666160708224330

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Heart failure (HF) is a major global problem in public health with no curative treatment currently available. Energy remodeling is one of the features in HF, preceding cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial functions and energy remodeling in HF including the energy starvation theory and energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF energy metabolism.

引用

页码：4823 / 4829

页数：7

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