Differential regulation of IGFBP-2 and IGFBP-5 gene expression by vitamin A status in Japanese quail

被引:8
|
作者
Fu, ZW [1 ]
Noguchi, T [1 ]
Kato, H [1 ]
机构
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Lab Nutr Biochem,Bunkyo Ku, Tokyo 1138657, Japan
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2001年 / 281卷 / 01期
关键词
insulin-like growth factor binding proteins-2 and-5; vitamin A deficiency; vitamin A repletion;
D O I
10.1152/ajpendo.2001.281.1.E138
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To investigate the involvement of the insulin-like growth factor (IGF) system in vitamin A (VA)-supported growth, we examined the effects of VA status on IGF binding protein (IGFBP)-2 and -5 gene expression in Japanese quail. VA deficiency caused a reduction in IGFBP-2 mRNA only in lung, without effect in other tissues. However, the expression of IGFBP-5 mRNA was more sensitive to the change of VA status. IGFBP-5 mRNA levels were significantly reduced by VA depletion in a tissue-specific manner, which preceded the decrease in body weight. A single injection of retinoic acid or retinol to VA-deficient quail did not affect the levels of IGFBP-2 mRNA, but it rapidly induced the expression of IGFBP-5 mRNAs in some tissues. These results are the first to show that gene expression of some IGFBPs in vivo are under the control of VA status and suggest a possible involvement of the IGF system in mediating the physiological actions of VA in the growth of Japanese quail.
引用
收藏
页码:E138 / E146
页数:9
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