Drug delivery system based on poly(ether-block-amide) and acrylic acid for controlled release of vancomycin

被引：6

作者：

Ortega, Alejandra ^{[1
]}

Ivan Melendez-Ortiz, H. ^{[2
]}

Garcia-Uriostegui, Lorena ^{[3
]}

Avila-Soria, Griselda ^{[4
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Circuito Exterior S-N,Ciudad Univ, Mexico City 04510, DF, Mexico

[2] CONACyT, Ctr Invest Quim Aplicada, Blvd Enrique Reyna Hermosillo 140, Saltillo 25294, Coahuila, Mexico

[3] Univ Guadalajara, CONACyT, DMCyP, Zapopan 45020, Jalisco, Mexico

[4] Univ Nacl Autonoma Mexico, Inst Marine Sci & Limnol ICML, Reef Syst Unit, Lab Ecol Evolutionary Dev Biol, Puerto Morelos 77580, Quintana Roo, Mexico

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2018年 / 135卷 / 04期

关键词：

biomedical applications; drug delivery systems; grafting; polyamides; ELECTRON-BEAM IRRADIATION; BIOMEDICAL APPLICATIONS; THERMOPLASTIC ELASTOMERS; PH; SURFACES; BEHAVIOR; FILMS;

D O I：

10.1002/app.45745

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(ether-block-amide) (PEBA) films were grafted with acrylic acid (AAc) by gamma radiation, using the oxidative pre-irradiation technique. The effect of dose, monomer concentration, temperature, and reaction time on the graft percentage of AAc onto PEBA was studied. The modified material PEBA-g-AAc was characterized by Fourier infrared spectroscopy (FTIR), scanning electron microscopy, and water contact angle. It was found that PEBA films did not suffer degradation at low doses (<30kGy) during the grafting process. Additionally, PEBA-g-AAc was proved as drug delivery system using vancomycin as drug model. The PEBA-g-AAc with 39 and 98% of AAc loaded 63 and 98 mgg(-1), respectively. The release profiles showed a sustained delivery by 48 h with a partial retention of drug, which depends of grafting percentage. The microbiological tests showed that PEBA-g-AAc was able to inhibit the growing of Staphylococcus aureus in three consecutive challenges. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45745.

引用

页数：8

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