Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs

被引：32

作者：

Shin, Eun-Joo ^{[1
]}

Bach, Jae-Hyung ^{[1
]}

Lee, Sung Youl ^{[1
]}

Kim, Jeong Min ^{[2
]}

Lee, Jinhwa ^{[2
]}

Hong, Jau-Shyong ^{[3
]}

Nabeshima, Toshitaka ^{[4
]}

Kim, Hyoung-Chun ^{[1
]}

机构：

[1] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 200701, South Korea

[2] Green Cross Co, Cent Res Ctr, Yongin 446799, South Korea

[3] NIEHS, Neuropharmacol Sect, Lab Pharmacol & Chem, NIH, Res Triangle Pk, NC 27709 USA

[4] Meijo Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2011年 / 116卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

dextromethorphan; dimemorfan; 3-hydroxymorphinan; neuroprotection; neuropsychotoxicity; neurodegenerative disorder; METHYL-D-ASPARTATE; NMDA RECEPTOR ANTAGONISTS; EXCITATORY AMINO-ACIDS; LONG-TERM POTENTIATION; POSTOPERATIVE PAIN; INDUCED SEIZURES; BINDING-SITES; RAT-BRAIN; DEXTRORPHAN; DIMEMORFAN;

D O I：

10.1254/jphs.11R02CR

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.

引用

页码：137 / 148

页数：12

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