White Matter Volume in the Brainstem and Inferior Parietal Lobule is Related to Motor Performance in Children with Autism Spectrum Disorder: A Voxel-Based Morphometry Study

被引：23

作者：

Hanaie, Ryuzo ^{[1
]}

Mohri, Ikuko ^{[1
,2
,3
]}

Kagitani-Shimono, Kuriko ^{[2
,3
]}

Tachibana, Masaya ^{[2
,3
]}

Matsuzaki, Junko ^{[1
,2
]}

Hirata, Ikuko ^{[3
]}

Nagatani, Fumiyo ^{[1
]}

Watanabe, Yoshiyuki ^{[4
]}

Fujita, Norihiko ^{[4
]}

Taniike, Masako ^{[1
,2
,3
]}

机构：

[1] Osaka Univ, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, United Grad Sch Child Dev, Div Dev Neurosci, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Grad Sch Med, Dept Pediat, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Grad Sch Med, Dept Diagnost & Intervent Radiol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

AUTISM RESEARCH | 2016年 / 9卷 / 09期

关键词：

voxel-based morphometry; white matter; brainstem; autism spectrum disorder; motor; HIGH-FUNCTIONING AUTISM; SENSORIMOTOR SYSTEM; ASPERGERS-DISORDER; SYMPTOM SEVERITY; CONNECTIVITY; MICROSTRUCTURE; DYSFUNCTION; DEFICITS; INFANTS; CORTEX;

D O I：

10.1002/aur.1605

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Many studies have reported poor motor performance in autism spectrum disorder (ASD); however, the underlying brain mechanisms remain unclear. Recent neuroimaging studies have suggested that abnormalities of the white matter (WM) are related to the features of ASD. In this study, we used voxel-based morphometry (VBM) to investigate which WM regions correlate with motor performance in children with ASD, and whether the WM volume in those brain regions differed between children with ASD and typically developing (TD) children. The subjects included 19 children with ASD and 20 TD controls. Motor performance was assessed using the Movement Assessment Battery for Children 2 (M-ABC 2). Children with ASD showed poorer motor performance than did the controls. There was a significant positive correlation between the total test score on the M-ABC 2 and the volume of WM in the brainstem and WM adjacent to the left supramarginal gyrus (SMG). In addition, compared with the TD controls, children with ASD had a decreased volume of WM in the brainstem and adjacent to the left intraparietal sulcus, which is close to the SMG. These findings suggest that structural changes in the WM in the brainstem and left inferior parietal lobule may contribute to poor motor performance in children with ASD. (C) 2016 International Society for Autism Research, Wiley Periodicals, Inc.

引用

页码：981 / 992

页数：12

共 92 条

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