Crassifolins Q-W: Clerodane Diterpenoids From Croton crassifolius With Anti-Inflammatory and Anti-Angiogenesis Activities

被引：14

作者：

Li, Canjie ^{[1
]}

Sun, Xin ^{[1
,2
]}

Yin, Wenjing ^{[3
]}

Zhan, Zhaochun ^{[1
]}

Tang, Qing ^{[1
]}

Wang, Wenzhi ^{[1
]}

Zhuo, Xuefang ^{[1
]}

Wu, Zhongnan ^{[2
]}

Zhang, Haipeng ^{[3
]}

Li, Yaolan ^{[1
]}

Zhang, Yubo ^{[1
,3
]}

Wang, Guocai ^{[1
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Peoples R China

[2] Jinan Univ, Affiliated Hosp 1, Guangzhou, Peoples R China

[3] Jinan Univ, Guangdong Clin Translat Ctr Targeted Drug, Sch Med, Dept Pharmacol, Guangzhou, Peoples R China

来源：

FRONTIERS IN CHEMISTRY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Euphorbiaceae; Croton crassifolius; clerodane diterpenoids; anti-inflammatory activity; anti-angiogenic activity; PHORBOL ESTERS; APOPTOSIS; ROOTS;

D O I：

10.3389/fchem.2021.733350

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Seven new clerodane diterpenoids, crassifolins Q-W (1-7), along with five known analogues (8-12), were isolated from the roots of Croton crassifolius. Their structures were identified by comprehensive spectroscopic analysis (UV, IR, NMR, and HR-ESI-MS), and their absolute configurations were determined by ECD spectra and X-ray crystallography. The activities of compounds 1-5 against inflammatory cytokines IL-6 and TNF-alpha levels on LPS-induced RAW 264.7 macrophages were assessed, and compound 5 showed the most significant activity with the secretion levels of IL-6 and TNF-alpha at 32.78 and 12.53%, respectively. Moreover, compounds 1-5 were screened for their anti-angiogenesis using a human umbilical vein endothelial cells in vitro mode; the results showed all of them exhibited obvious anti-angiogenesis activities, in particular, compound 5 showed the strongest anti-angiogenesis effect in the range of 6.25-50 mu M.

引用

页数：12

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