A combinatorial protecting group strategy for oligonucleotide synthesis

被引：4

作者：

Leikauf, E ^{[1
]}

Barnekow, F ^{[1
]}

Koster, H ^{[1
]}

机构：

[1] UNIV HAMBURG,FAC CHEM,DEPT BIOCHEM & MOLEC BIOL,D-20146 HAMBURG,GERMANY

来源：

TETRAHEDRON | 1996年 / 52卷 / 20期

关键词：

D O I：

10.1016/0040-4020(96)00337-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel 5'-3' directed DNA synthesis mill be described Together with additional investigations on model compounds a synthetic strategy is established which allows multiselective deprotections. This offers the potential to either generate oligonucleotides in different sequence specific protection/functionalization states or to create a combinatorial set of molecules available for specific molecular interaction or recognition experiments. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6913 / 6930

页数：18

共 25 条

[1] DRUG DISCOVERY ON THE ASSEMBLY-LINE [J].

ALPER, J .

SCIENCE, 1994, 264 (5164) :1399-1401

[2] THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH AND THEIR APPLICATIONS [J].

BEAUCAGE, SL ;

IYER, RP .

TETRAHEDRON, 1993, 49 (28) :6123-6194

[3]

COHEN JS, 1994, SCI AM DEC, P50

[4] THE FLUOREN-9-YLMETHOXYCARBONYL GROUP FOR THE PROTECTION OF HYDROXY-GROUPS - ITS APPLICATION IN THE SYNTHESIS OF AN OCTATHYMIDYLIC ACID FRAGMENT [J].

GIOELI, C ;

CHATTOPADHYAYA, JB .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (12) :672-674

[5] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS [J].

GORDON, EM ;

BARRETT, RW ;

DOWER, WJ ;

FODOR, SPA ;

GALLOP, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1385-1401

[6] THE 2-NITROPHENYLSULFENYL (NPS) GROUP FOR THE PROTECTION OF AMINO FUNCTIONS OF CYTIDINE, ADENOSINE, GUANOSINE AND THEIR 2'-DEOXYSUGAR DERIVATIVES [J].

HEIKKILA, J ;

BALGOBIN, N ;

CHATTOPADHYAYA, J .

ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1983, 37 (09) :857-862

[7] THE PARA-NITROPHENYLETHYL (NPE) GROUP - A VERSATILE NEW BLOCKING GROUP FOR PHOSPHATE AND AGLYCONE PROTECTION IN NUCLEOSIDES AND NUCLEOTIDES [J].

HIMMELSBACH, F ;

SCHULZ, BS ;

TRICHTINGER, T ;

CHARUBALA, R ;

PFLEIDERER, W .

TETRAHEDRON, 1984, 40 (01) :59-72

[8] IMPROVEMENTS IN THE PHOSPHOTRIESTER SYNTHESIS OF DEOXYRIBOOLIGONUCLEOTIDES - THE USE OF HINDERED PRIMARY AMINES AND A NEW ISOLATION PROCEDURE [J].

HSIUNG, HM .

TETRAHEDRON LETTERS, 1982, 23 (49) :5119-5122

[9] DERIVATIVES OF SULFENIC ACIDS .10. THE REACTION OF 2,4-DINITROBENZENESULFENYL CHLORIDE WITH ALCOHOLS [J].

KHARASCH, N ;

MCQUARRIE, DP ;

BUESS, CM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (11) :2658-2660

[10]

KOSTER H, 1985, NATURAL PRODUCTS CHE, P227

← 1 2 3 →