Ubiquitin-Conjugating Enzymes in Cancer

被引：36
作者：
Bui, Quyen Thu [1 ,2 ]
Hong, Jeong Hee [3 ]
Kwak, Minseok [4 ]
Lee, Ji Yeon [5 ]
Lee, Peter Chang-Whan [1 ,2 ]
机构：
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Biomed Sci, Seoul 05505, South Korea
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Lung Canc Res Ctr, Seoul 05505, South Korea
[3] Gachon Univ, Coll Med, Dept Physiol, Incheon 21999, South Korea
[4] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea
[5] Catholic Univ, Seoul St Marys Hosp, Dept Med, Div Rheumatol, Seoul 06591, South Korea
来源：
CELLS | 2021年 / 10卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
ubiquitin-conjugating enzyme; cancer; ubiquitination; CELL-CYCLE GENE; BREAST-CANCER; IN-VITRO; UBC13-UEV1A INTERACTION; PROGNOSTIC-SIGNIFICANCE; TUMOR-SUPPRESSOR; CARCINOMA-CELLS; UBE2O PROMOTES; MARINE SPONGE; HUMAN CDC34;
D O I：
10.3390/cells10061383
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)-E2 (conjugating)-E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies.
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页数：16
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