Mechanical Properties and In Vitro Bioactivity of Nano-Fibrous Hydroxyapatite/Chitosan Composites

被引：4
作者：
Yan, Wei [1 ]
Xia, Ling Li [2 ]
Zhang, Cai Yun [3 ]
机构：
[1] Anhui San Lian Univ, Sch Nursing, Hefei 230031, Anhui, Peoples R China
[2] Army Officer Acad PLA, Armor Forces Dept, Hefei 230031, Anhui, Peoples R China
[3] Anhui Univ Tradit Chinese Med, Coll Pharm, Hefei 230031, Anhui, Peoples R China
来源：
NANOSCIENCE AND NANOTECHNOLOGY LETTERS | 2017年 / 9卷 / 07期
关键词：
Hydroxyapatite/Chitosan Nano-Fibrous; In Vitro; Bio-Compatibility; CHITOSAN; SCAFFOLDS;
D O I：
10.1166/nnl.2017.2421
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Hydroxyapatite/chitosan (HA/CS) nano-fibrous composites with HA contents of 0-80 wt% were prepared by in situ hybridization. The hydroxyapatite nano-fibers with average diameter of about 3 nm and length of 20-60 nm homogeneously disperse in the chitosan matrix. The compressive strength of these nano-fibrous HA/CS composites increase with the increasing HA content and reached the highest values of 178 MPa. The results of in vitro tests in simulated body fluid solutions indicate that the HA/CS bio-composites have good biodegradability and bioactivity. All the results suggested that the HA/CS bio-composites are appropriate to be applied as bone substitute in bone tissue engineering.
引用
收藏
页码：1038 / 1042
页数：5
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