Mechanical Properties and In Vitro Bioactivity of Nano-Fibrous Hydroxyapatite/Chitosan Composites

被引：4

作者：

Yan, Wei ^{[1
]}

Xia, Ling Li ^{[2
]}

Zhang, Cai Yun ^{[3
]}

机构：

[1] Anhui San Lian Univ, Sch Nursing, Hefei 230031, Anhui, Peoples R China

[2] Army Officer Acad PLA, Armor Forces Dept, Hefei 230031, Anhui, Peoples R China

[3] Anhui Univ Tradit Chinese Med, Coll Pharm, Hefei 230031, Anhui, Peoples R China

来源：

NANOSCIENCE AND NANOTECHNOLOGY LETTERS | 2017年 / 9卷 / 07期

关键词：

Hydroxyapatite/Chitosan Nano-Fibrous; In Vitro; Bio-Compatibility; CHITOSAN; SCAFFOLDS;

D O I：

10.1166/nnl.2017.2421

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Hydroxyapatite/chitosan (HA/CS) nano-fibrous composites with HA contents of 0-80 wt% were prepared by in situ hybridization. The hydroxyapatite nano-fibers with average diameter of about 3 nm and length of 20-60 nm homogeneously disperse in the chitosan matrix. The compressive strength of these nano-fibrous HA/CS composites increase with the increasing HA content and reached the highest values of 178 MPa. The results of in vitro tests in simulated body fluid solutions indicate that the HA/CS bio-composites have good biodegradability and bioactivity. All the results suggested that the HA/CS bio-composites are appropriate to be applied as bone substitute in bone tissue engineering.

引用

页码：1038 / 1042

页数：5

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