HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults

被引：9

作者：

Matthews, Philippa C. ^{[1
,3
]}

Carlson, Jonathan M. ^{[9
]}

Beloukas, Apostolos ^{[5
]}

Malik, Amna ^{[2
]}

Jooste, Pieter ^{[13
]}

Ogwu, Anthony ^{[10
,16
]}

Shapiro, Roger ^{[10
,16
]}

Riddell, Lynn ^{[6
]}

Chen, Fabian ^{[7
]}

Luzzi, Graz ^{[8
]}

Jesuthasan, Gerald ^{[3
]}

Jeffery, Katie ^{[3
]}

Jojic, Nebojsa ^{[9
]}

Ndung'u, Thumbi ^{[11
,14
,15
,17
]}

Carrington, Mary ^{[11
,12
]}

Goulder, Philip J. R. ^{[2
,14
]}

Geretti, Anna Maria ^{[5
]}

Klenerman, Paul ^{[1
,3
,4
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Oxford, England

[2] Univ Oxford, Dept Pediat, Oxford, England

[3] Oxford Univ Hosp NHS Trust, Dept Infect Dis & Microbiol, Oxford, England

[4] John Radcliffe Hosp, NIHR Biomed Res Ctr, Oxford OX3 9DU, England

[5] Univ Liverpool, Inst Infect & Global Hlth, Dept Clin Infect Microbiol & Immunol, Cliftonville, England

[6] Northampton Gen Hosp, Integrated Sexual Hlth Serv, Cliftonville, England

[7] Royal Berkshire Hosp, Dept Sexual Hlth, Reading RG1 5AN, Berks, England

[8] High Wycombe Hosp, Dept Sexual Hlth, Wycombe, Bucks, England

[9] ESci Grp, Microsoft Res, Redmond, WA USA

[10] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, 665 Huntington Ave, Boston, MA 02115 USA

[11] MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA

[12] Frederick Natl Lab Canc Res, Leidos Biomed Res, Expt Immunol Lab, Canc & Inflammat Program, College Pk, MD USA

[13] Kimberley Hosp, Dept Pediat, Northern Cape, South Africa

[14] Nelson R Mandela Sch Med, Doris Duke Med Res Inst, HIV Pathogenesis Programme, Durban, South Africa

[15] Univ KwaZulu Natal, KwaZulu Natal Res Inst TB & HIV, Potchefstroom, South Africa

[16] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana

[17] Max Planck Inst Infect Biol, Berlin, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 08期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

HBV; HIV; coinfection; immunology; CD8+T cells; HLA; HBeAg (hepatitis B e antigen); viral hepatitis; Africa; VIRUS INFECTION; ASSOCIATION; SELECTION;

D O I：

10.1093/infdis/jiv592

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies.

引用

页码：1248 / 1252

页数：5

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