HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults

被引：9

作者：

Matthews, Philippa C. ^{[1
,3
]}

Carlson, Jonathan M. ^{[9
]}

Beloukas, Apostolos ^{[5
]}

Malik, Amna ^{[2
]}

Jooste, Pieter ^{[13
]}

Ogwu, Anthony ^{[10
,16
]}

Shapiro, Roger ^{[10
,16
]}

Riddell, Lynn ^{[6
]}

Chen, Fabian ^{[7
]}

Luzzi, Graz ^{[8
]}

Jesuthasan, Gerald ^{[3
]}

Jeffery, Katie ^{[3
]}

Jojic, Nebojsa ^{[9
]}

Ndung'u, Thumbi ^{[11
,14
,15
,17
]}

Carrington, Mary ^{[11
,12
]}

Goulder, Philip J. R. ^{[2
,14
]}

Geretti, Anna Maria ^{[5
]}

Klenerman, Paul ^{[1
,3
,4
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Oxford, England

[2] Univ Oxford, Dept Pediat, Oxford, England

[3] Oxford Univ Hosp NHS Trust, Dept Infect Dis & Microbiol, Oxford, England

[4] John Radcliffe Hosp, NIHR Biomed Res Ctr, Oxford OX3 9DU, England

[5] Univ Liverpool, Inst Infect & Global Hlth, Dept Clin Infect Microbiol & Immunol, Cliftonville, England

[6] Northampton Gen Hosp, Integrated Sexual Hlth Serv, Cliftonville, England

[7] Royal Berkshire Hosp, Dept Sexual Hlth, Reading RG1 5AN, Berks, England

[8] High Wycombe Hosp, Dept Sexual Hlth, Wycombe, Bucks, England

[9] ESci Grp, Microsoft Res, Redmond, WA USA

[10] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, 665 Huntington Ave, Boston, MA 02115 USA

[11] MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA

[12] Frederick Natl Lab Canc Res, Leidos Biomed Res, Expt Immunol Lab, Canc & Inflammat Program, College Pk, MD USA

[13] Kimberley Hosp, Dept Pediat, Northern Cape, South Africa

[14] Nelson R Mandela Sch Med, Doris Duke Med Res Inst, HIV Pathogenesis Programme, Durban, South Africa

[15] Univ KwaZulu Natal, KwaZulu Natal Res Inst TB & HIV, Potchefstroom, South Africa

[16] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana

[17] Max Planck Inst Infect Biol, Berlin, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 08期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

HBV; HIV; coinfection; immunology; CD8+T cells; HLA; HBeAg (hepatitis B e antigen); viral hepatitis; Africa; VIRUS INFECTION; ASSOCIATION; SELECTION;

D O I：

10.1093/infdis/jiv592

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies.

引用

页码：1248 / 1252

页数：5

共 50 条

[1] Hepatitis B seroprevalence among HIV-positive adults in the Free State, South Africa
Muir, Devon
Vawda, Sabeehah
Bester, Phillip A.
van Rooyen, Cornel
Goedhals, Dominique
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE, 2025, 26 (01)
[2] Immune response to hepatitis B vaccination in HIV-positive adults with isolated antibodies to HBV core antigen
Kaech, Chloe
Pache, Isabelle
Buergisser, Philippe
Elzi, Luigia
Darling, Katharine E. A.
Cavassini, Matthias
JOURNAL OF INFECTION, 2012, 65 (02) : 157 - 164
[3] Increased exposure to hepatitis B virus infection in HIV-positive South African antenatal women
Burnett, R. J.
Ngobeni, J. M.
Francois, G.
Hoosen, A. A.
Leroux-Roels, G.
Meheus, A.
Mphahlele, M. J.
INTERNATIONAL JOURNAL OF STD & AIDS, 2007, 18 (03) : 152 - 156
[4] Hepatitis E virus infection in the HIV-positive patient
Debes, Jose D.
Pisano, Maria Belen
Lotto, Martin
Re, Viviana
JOURNAL OF CLINICAL VIROLOGY, 2016, 80 : 102 - 106
[5] Molecular analysis of occult hepatitis B infection among Iranian HIV-positive patients
Mohraz, Minoo
Jafari, Rezvaneh
Poortahmasebi, Vahdat
Sadeghi, Ahmadreza
Hajabdolbaghi, Mahboobeh
Rasoolinejad, Mehrnaz
Forooghi, Maryam
Norouzi, Mehdi
Poorebrahim, Mansour
Khamseh, Azam
Karkhaneh, Masoud
Alavian, Seyed Moayed
Ebrahimian, Arefeh
Jazayeri, Seyed Mohammad
FUTURE VIROLOGY, 2016, 11 (07) : 497 - 508
[6] Molecular characterization of hepatitis B virus X gene in HIV-positive South Africans
Gededzha, Maemu P.
Sondlane, Tsakani H.
Malinga, Lesibana A.
Burnett, Rosemary J.
Lebelo, Ramokone L.
Blackard, Jason T.
Mphahlele, M. Jeffrey
Selabe, Selokela G.
VIRUS GENES, 2018, 54 (02) : 190 - 198
[7] High Rates of Occult Hepatitis B Virus Infection in HIV-Positive Individuals Initiating Antiretroviral Therapy in Botswana
Ryan, Kathleen
Anderson, Motswedi
Gyurova, Ivayla
Ambroggio, Lilliam
Moyo, Sikhulile
Sebunya, Teresa
Makhema, Joseph
Marlink, Richard
Essex, Max
Musonda, Rosemary
Gaseitsiwe, Simani
Blackard, Jason T.
OPEN FORUM INFECTIOUS DISEASES, 2017, 4 (04):
[8] Hepatitis B, hepatitis C, and mortality among HIV-positive individuals
Thornton, Alicia C.
Jose, Sophie
Bhagani, Sanjay
Chadwick, David
Dunn, David
Gilson, Richard
Main, Janice
Nelson, Mark
Rodger, Alison
Taylor, Chris
Youssef, Elaney
Leen, Clifford
Gompels, Mark
Kegg, Stephen
Schwenk, Achim
Sabin, Caroline
AIDS, 2017, 31 (18) : 2525 - 2532
[9] Response of hepatitis B virus to antiretroviral treatment containing lamivudine in HBsAg-positive and HBsAg-negative HIV-positive South African adults
Singh, Lanish
Bell, Trevor Graham
Yousif, Mukhlid
Kramvis, Anna
JOURNAL OF MEDICAL VIROLOGY, 2019, 91 (05) : 758 - 764
[10] Membranous nephropathy in an HIV-positive patient complicated with hepatitis B virus infection
Akihiko Numata
Tetsu Akimoto
Masaki Toshima
Yoshitaka Iwazu
Naoko Otani
Takuya Miki
Taro Sugase
Osamu Saito
Yoshitomo Hamano
Fumi Takemoto
Yoshihiko Ueda
Shigeaki Muto
Eiji Kusano
Clinical and Experimental Nephrology, 2011, 15 : 769 - 773

← 1 2 3 4 5 →