First stereoselective synthesis of meso-secoisolariciresinol and comparison of its biological activity with (+) and (-)-secoisolariciresinol

被引：20

作者：

Sugahara, Takuya ^{[1
]}

Yamauchi, Satoshi ^{[1
]}

Kondo, Ai ^{[1
]}

Ohno, Furni ^{[1
]}

Tominaga, Siori ^{[1
]}

Nakashima, Yuki ^{[1
]}

Kishida, Taro ^{[1
]}

Akiyama, Koichi ^{[2
]}

Maruyama, Masafurni ^{[1
]}

机构：

[1] Ehime Univ, Fac Agr, Matsuyama, Ehime 7908566, Japan

[2] Ehime Univ, Integrated Ctr Sci, Matsuyama, Ehime 7908566, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 12期

关键词：

lignan; immunosuppressive activity; cytotoxic activity;

D O I：

10.1271/bbb.70358

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first stereoselective synthesis of meso-secoisolariciresinol is reported. A comparison of the cytotoxic and immunosuppressive activity between meso-secoisolariciresinol and optically active secoisolariciresinols was similarly performed for the first time. Both enantiomers of secoisolariciresinol accelerated IgM production, although meso-secoisolariciresinol did not affect IgM production. Only meso-secoisolariciresinol showed cytotoxic activity.

引用

页码：2962 / 2968

页数：7

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