Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions

被引：27

作者：

Schindler, Daniel ^{[1
]}

Dai, Junbiao ^{[2
]}

Cai, Yizhi ^{[1
,2
]}

机构：

[1] Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England

[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Synthet Biol, Ctr Synthet Genom, Shenzhen 518055, Peoples R China

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2018年 / 46卷

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 中国国家自然科学基金;

关键词：

CHEMICAL-SYNTHESIS; DIVERSITY;

D O I：

10.1016/j.cbpa.2018.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10 000 bps and turnaround times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions.

引用

页码：56 / 62

页数：7

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