Piezoelectric poly(vinylidene fluoride) microstructure and poling state in active tissue engineering

被引:94
作者
Ribeiro, Clarisse [1 ,2 ]
Correia, Daniela M. [1 ,3 ]
Ribeiro, Sylvie [1 ]
Sencadas, Vitor [1 ,4 ]
Botelho, Gabriela [3 ]
Lanceros-Mendez, Senentxu [1 ,2 ]
机构
[1] Univ Minho, Ctr Dept Fis, Braga, Portugal
[2] INL Int Iberian Nanotechnol Lab, Braga, Portugal
[3] Univ Minho, Ctr Dept Quim, Braga, Portugal
[4] Politecn Cavado, Escola Super Tecnol, Inst, Barcelos, Portugal
来源
ENGINEERING IN LIFE SCIENCES | 2015年 / 15卷 / 04期
关键词
Cell behavior; Physical stimuli; Piezoelectric polymer; Poly(vinylidene fluoride); Surface topography; SURFACE-CHEMISTRY; PVDF MEMBRANES; DRUG-DELIVERY; ELECTROSPUN; PROLIFERATION; MORPHOLOGY; CELLS; DIFFERENTIATION; TOPOGRAPHY; OSTEOBLAST;
D O I
10.1002/elsc.201400144
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Tissue engineering strategies rely on suitable membranes and scaffolds, providing the necessary physicochemical stimuli to specific cells. This review summarizes the main results on piezoelectric polymers, in particular poly(vinylidene fluoride), for muscle and bone cell culture. Further, the relevance of polymer microstructure and surface charge on cell response is demonstrated. Together with the necessary biochemical cues, the proper design of piezoelectric polymers can open the way to novel and more reliable tissue engineering strategies for cells in which electromechanical stimuli are present in their environment.
引用
收藏
页码:351 / 356
页数:6
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