HISTAMINE AND TNF-α RELEASE BY RAT PERITONEAL MAST CELLS STIMULATED WITH TRICHOMONAS VAGINALIS

被引：18

作者：

Im, S. J. ^{[1
]}

Ahn, M. N. ^{[1
]}

Han, I. H. ^{[1
]}

Song, H. O. ^{[2
]}

Kim, Y. S. ^{[3
]}

Kim, H. M. ^{[4
]}

Ryu, J. S. ^{[1
]}

机构：

[1] Hanyang Univ, Dept Environm Biol & Med Parasitol, Coll Med, Seoul 133791, South Korea

[2] Catholic Univ Daegu, Dept Parasitol, Sch Med, Taegu 705718, South Korea

[3] Hanyang Univ, Dept Biochem & Mol Biol, Coll Med, Seoul 133791, South Korea

[4] Kyung Hee Univ, Dept Pharmacol, Coll Oriental Med, Inst Oriental Med, Seoul 130701, South Korea

来源：

PARASITE | 2011年 / 18卷 / 01期

关键词：

Trichomonas vaginalis; rat; mast cell; migration; histamine; TNF-alpha; TUMOR-NECROSIS-FACTOR; IMMUNE-RESPONSE; IN-VIVO; INFECTION; ASSOCIATION; MIGRATION; HEPARIN; MOUSE; MICE;

D O I：

10.1051/parasite/2011181049

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-alpha and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-alpha. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.

引用

页码：49 / 55

页数：7

共 39 条

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