Four New Acyclic Diterpenes From Siegesbeckia orientalis

被引：5

作者：

Trang, Do Thi ^{[1
]}

Huong, Phan Thi Thanh ^{[1
]}

Cuc, Nguyen Thi ^{[1
]}

Dung, Duong Thi ^{[1
]}

Trang, Bui Thi Thu ^{[2
]}

Nhiem, Nguyen Xuan ^{[1
,3
]}

Tai, Bui Huu ^{[1
,3
]}

Van Kiem, Phan ^{[1
,3
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] Hanoi Univ Ind, Hanoi, Vietnam

[3] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol, Hanoi, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2021年 / 16卷 / 11期

关键词：

compositae; Siegesbeckia orientalis; acyclic diterpene; siegetalis; xanthine oxidase activity; MOLECULAR DOCKING; CONSTITUENTS;

D O I：

10.1177/1934578X211056140

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new acyclic diterpenes, siegetalises A-D (1-4), were isolated from the aerial parts of Siegesbeckia orientalis. Their chemical structures were elucidated by extensive analysis of high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance spectral data. The effects of the isolated compounds on the activity of xanthine oxidase were evaluated by the oxidative reaction with xanthine as a substrate. At a concentration of 50 mu M, compounds 1-4 exhibited xanthine oxidase inhibitory activity at levels of 13.59% +/- 0.51%, 19.64% +/- 1.54%, 17.45% +/- 1.26%, and 21.36% +/- 1.40%, respectively.

引用

页数：6

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