Trifluoromethylsulfonyl pyridinium salt for trifluoromethythiolation of indoles

被引：1
作者：
Yang, Xin-Jun [1 ]
Lin, Jin-Hong [1 ,2 ]
Xiao, Ji-Chang [1 ]
机构：
[1] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Chinese Acad Sci, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
[2] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2022年 / 263卷
基金：
中国国家自然科学基金;
关键词：
Trifluoromethylsulfonyl pyridinium salt; Trifluoromethylthiolation; Indoles; Fluorine; Trifluoromethanesulfonic anhydride; FREE DIRECT TRIFLUOROMETHYLTHIOLATION; HYPERVALENT IODINE REAGENT; ELECTROPHILIC TRIFLUOROMETHYLTHIOLATION; SODIUM TRIFLUOROMETHANESULFINATE; DIFLUOROCARBENE; CF3SO2NA; INSIGHT;
D O I：
10.1016/j.jfluchem.2022.110047
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The trifluoromethylsulfonyl pyridinium salt (TFSP) was used as a CF3S source for the trifluoromethylthiolation of indole derivatives. It is proposed that TFSP is reduced in the presence of diethyl phosphite and NaCl. The pro-tocol features a facile access to the CF3S source, and high efficiency and transition-metal free conditions for trifluoromethylthiolation.
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页数：8
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