Transition Metal-Catalyzed Reactions and Solid-Phase Synthesis: A Convenient Blend

被引：2

作者：

Cornier, Patricia G. ^{[1
]}

Delpiccolo, Carina M. L. ^{[1
]}

Martiren, Nadia L. ^{[1
]}

Mata, Ernesto G. ^{[1
]}

Mendez, Luciana ^{[1
]}

Squizatto, Caterina Permingeat ^{[1
]}

Pizzio, Marianela G. ^{[1
]}

机构：

[1] Natl Univ Rosario, Fac Biochem & Pharmaceut Sci, Rosario Inst Chem CONICET UNR, Dept Organ Chem, Suipacha 531, RA-2000 Rosario, Argentina

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 38期

关键词：

CuAAC reactions; Pd-catalyzed couplings; Ru-mediated metathesis; Solid-phase synthesis; Transition-metal catalysis; AZIDE-ALKYNE CYCLOADDITION; CROSS-COUPLING REACTIONS; OLEFIN-METATHESIS; PEPTIDES; RESIN; INHIBITORS; CHEMISTRY; LINKER; ACID; OPTIMIZATION;

D O I：

10.1002/ejoc.202200526

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transition metal-catalyzed, C-C and C-N bond-forming reactions have made an enormous impact in the way complex molecules are assembled. The benefits of solid-phase chemistry soon made this type of reaction applicable to solid-supported processes. In this review, we report the most recent applications and possibilities of this combination. Remarkably, the solid-phase CuAAC and ring-closing metathesis have demonstrated an important role in synthetic biology, alike more traditional Pd-catalyzed reactions, such as Suzuki-Miyaura, Heck, Sonogashira, which are valuable tools for accessing libraries of biologically relevant small molecules. Examples proved the validity of solid-phase transition metal-catalyzed reactions as a practical and fast strategy to cover the current organic chemistry demands.

引用

页数：21

共 147 条

[1] Solid-Phase Synthesis of Biaryl Cyclic Peptides Containing a 3-Aryltyrosine [J].