Effect of long-term administration of arachidonic acid on n-3 fatty acid deficient mice

被引:11
作者
Harauma, Akiko [1 ]
Tomita, Makiko [2 ]
Muto, Daiki [2 ]
Moriguchi, Toru [1 ,2 ]
机构
[1] Azabu Univ, Lab Funct Anal Marine Mat, Sch Life & Environm Sci, Sagamihara, Kanagawa 2525201, Japan
[2] Azabu Univ, Lab Food & Nutr Sci, Dept Food & Life Sci, Sch Life & Environm Sci, Sagamihara, Kanagawa 2298501, Japan
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2015年 / 95卷
关键词
Arachidonic acid; Spontaneous motor activity; Motor coordination; Rota-Rod test; Brain function; Mice; AGED RATS; SPATIAL COGNITION; BRAIN; PERFORMANCE; INFANTS; LIVER; DIET; SUPPLEMENTATION; NUTRITION; PREGNANCY;
D O I
10.1016/j.plefa.2014.12.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of long-term oral administration of arachidonic acid (ARA, 240 mg/kg/day) on brain function was assessed for mice maintained on an n-3 fatty acid adequate or deficient diet. The administration of ARA for 13 weeks resulted in an elevation of spontaneous motor activity, or the tendency thereof, in both the n-3 fatty acid adequate and deficient groups. However, the n-3 fatty acid deficient mice that were administered with ARA revealed marked deterioration in motor function in a motor coordination test. In the experiment to investigate changes over time, the motor activity of the ARA-administered group continued to increase mildly in n-3 deficient mice, although that of the control group showed a decrease involving habituation for both diet groups from the second week. The fatty acid composition of the brain at the end of the behavioral experiments indicated an increase in the levels of ARA and other n-6 fatty acids, as well as a decrease in the levels of docosahexaenoic acid. These results suggest that long-term administration of ARA causes an increase of futile spontaneous motor activity and the diminution of motor function by aggravation of n-3 fatty acid deficiency. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:41 / 45
页数:5
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