Protective effect of calcium folinate against methotrexate-induced endosalpinx damage in rats

被引：6
作者：
Yang, Xiao-Jun [1 ]
Chen, Yan-Ping [1 ]
Wang, Han-Chu [1 ]
Zhao, Jing [2 ]
Zheng, Fei-Yun [1 ]
机构：
[1] Wenzhou Med Coll, Affiliated Hosp 1, Dept Obstet & Gynecol, Wenzhou 325000, Zhejiang, Peoples R China
[2] WenZhou Med Coll, Affiliated Hosp 1, Dept Pathol, Wenzhou 325000, Zhejiang, Peoples R China
来源：
FERTILITY AND STERILITY | 2011年 / 95卷 / 04期
关键词：
Methotrexate; calcium folinate; endosalpinx; morphology; immunohistochemistry; estrogen receptor; progesterone receptor; ECTOPIC PREGNANCY; MEDICAL-MANAGEMENT; TUBAL PREGNANCY; RISK-FACTORS; PROGESTERONE; EXPRESSION; RECEPTORS; INJECTION; ESTROGEN; OVIDUCT;
D O I：
10.1016/j.fertnstert.2010.08.028
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The aim of this study was to evaluate the protective effect of calcium folinate (CF) applied in 10% of the methotrexate (MTX) dosage against morphologic and steroid-receptor damage induced by MTX in rat endosalpinx. The result indicated that endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low-and high-dose MTX in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX. (Fertil Steril (R) 2011;95:1526-30. (C) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码：1526 / 1530
页数：5
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