Protective effect of calcium folinate against methotrexate-induced endosalpinx damage in rats

被引：6
作者：
Yang, Xiao-Jun [1 ]
Chen, Yan-Ping [1 ]
Wang, Han-Chu [1 ]
Zhao, Jing [2 ]
Zheng, Fei-Yun [1 ]
机构：
[1] Wenzhou Med Coll, Affiliated Hosp 1, Dept Obstet & Gynecol, Wenzhou 325000, Zhejiang, Peoples R China
[2] WenZhou Med Coll, Affiliated Hosp 1, Dept Pathol, Wenzhou 325000, Zhejiang, Peoples R China
来源：
FERTILITY AND STERILITY | 2011年 / 95卷 / 04期
关键词：
Methotrexate; calcium folinate; endosalpinx; morphology; immunohistochemistry; estrogen receptor; progesterone receptor; ECTOPIC PREGNANCY; MEDICAL-MANAGEMENT; TUBAL PREGNANCY; RISK-FACTORS; PROGESTERONE; EXPRESSION; RECEPTORS; INJECTION; ESTROGEN; OVIDUCT;
D O I：
10.1016/j.fertnstert.2010.08.028
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The aim of this study was to evaluate the protective effect of calcium folinate (CF) applied in 10% of the methotrexate (MTX) dosage against morphologic and steroid-receptor damage induced by MTX in rat endosalpinx. The result indicated that endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low-and high-dose MTX in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX. (Fertil Steril (R) 2011;95:1526-30. (C) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码：1526 / 1530
页数：5
相关论文
共 53 条
[1]   Ultrastructural characterization of whole hydrosalpinx from infertile Chinese women [J].
Ajonuma, LC ;
Ng, EHY ;
Chan, LN ;
Chow, PH ;
Kung, LS ;
Cheung, ANY ;
Ho, LS ;
Briton-Jones, C ;
Lok, IH ;
Haines, CJ ;
Chan, HC .
CELL BIOLOGY INTERNATIONAL, 2005, 29 (10) :849-856
[2]  
BAGSHAWE KD, 1964, J OBSTET GYN BR COMM, V71, P565
[3]   The medical management of ectopic pregnancy: A meta-analysis comparing "single dose" and "multidose" regimens [J].
Barnhart, KT ;
Gosman, G ;
Ashby, R ;
Sammel, M .
OBSTETRICS AND GYNECOLOGY, 2003, 101 (04) :778-784
[4]   Risk factors for ectopic pregnancy in women with symptomatic first-trimester pregnancies [J].
Barnhart, Kurt T. ;
Sammel, Mary D. ;
Gracia, Clarisa R. ;
Chittams, Jesse ;
Hummel, Amy C. ;
Shaunik, Alka .
FERTILITY AND STERILITY, 2006, 86 (01) :36-43
[5]   SPERM TRANSPORT IN THE HUMAN FEMALE REPRODUCTIVE-TRACT - A DYNAMIC INTERACTION [J].
BARRATT, CLR ;
COOKE, ID .
INTERNATIONAL JOURNAL OF ANDROLOGY, 1991, 14 (06) :394-411
[6]   Light and electron microscope examination of the effects of methotrexate on the endosalpinx [J].
Bayram, M ;
Ozogul, C ;
Dursun, A ;
Ercan, ZS ;
Isik, I ;
Dilekoz, E .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2005, 120 (01) :96-103
[7]   Examination of the rescue effects of folic acid on derangement of the tubo-ovarian ultrastructural architecture caused by methotrexate [J].
Bayram, Merih ;
Ozogul, Candan ;
Ercan, Z. Sevim ;
Dilekoz, Ergin ;
Soyer, Canan ;
Bayram, Orhan .
ADVANCES IN THERAPY, 2006, 23 (05) :772-777
[8]   METHOTREXATE - CLINICAL PHARMACOLOGY, CURRENT STATUS AND THERAPEUTIC GUIDELINES [J].
BLEYER, WA .
CANCER TREATMENT REVIEWS, 1977, 4 (02) :87-101
[9]   How to preserve fertility in young women exposed to chemotherapy? The role of GnRH agonist cotreatment in addition to Cryopreservation of embrya, oocytes, or ovaries [J].
Blumenfeld, Zeev .
ONCOLOGIST, 2007, 12 (09) :1044-1054
[10]   Progesterone receptor isoforms expression pattern in human chordomas [J].
Camacho-Arroyo, I ;
González-Agüero, G ;
Gamboa-Domínguez, A ;
Cerbón, MA ;
Ondarza, R .
JOURNAL OF NEURO-ONCOLOGY, 2000, 49 (01) :1-7
123456