Role of adult hippocampal neurogenesis in persistent pain

被引：103

作者：

Apkarian, A. Vania ^{[1
]}

Mutso, Amelia A. ^{[1
]}

Centeno, Maria V. ^{[1
]}

Kan, Lixin ^{[2
]}

Wu, Melody ^{[3
]}

Levinstein, Marjorie ^{[3
]}

Banisadr, Ghazal ^{[4
]}

Gobeske, Kevin T. ^{[2
]}

Miller, Richard J. ^{[4
]}

Radulovic, Jelena ^{[5
]}

Hen, Rene ^{[3
]}

Kessler, John A. ^{[2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Physiol, 7-705 Tarry Bldg, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA

[3] Columbia Univ, New York Psychiat Inst, Dept Pharmacol, New York, NY USA

[4] Northwestern Univ, Feinberg Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

来源：

PAIN | 2016年 / 157卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Inflammatory; Neuropathic; Learning; Mood; Neurogenesis; PERIPHERAL-NERVE INJURY; LONG-TERM POTENTIATION; CHRONIC BACK-PAIN; NEUROPATHIC PAIN; FUNCTIONAL CONNECTIVITY; MOLECULAR-MECHANISMS; MEMORY TRACES; DENTATE GYRUS; MICE; RATS;

D O I：

10.1097/j.pain.0000000000000332

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet, the role of AHN in development of persistent pain has remained unexplored. In this study, we test the influence of AHN in postinjury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN. Downregulating neurogenesis reversibly diminished or blocked persistent pain; oppositely, upregulating neurogenesis led to prolonged persistent pain. Moreover, we could dissociate negative mood from persistent pain. These results suggest that AHN-mediated hippocampal learning mechanisms are involved in the emergence of persistent pain.

引用

页码：418 / 428

页数：11

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