Predictors of survival in spinocerebellar ataxia type 2 population from Southern Italy

被引：7

作者：

Antenora, Antonella ^{[1
]}

Bruzzese, Dario ^{[2
]}

Lieto, Maria ^{[1
]}

Roca, Alessandro ^{[1
]}

Florio, Maria Teresa ^{[1
]}

Peluso, Silvio ^{[1
]}

Sacca, Francesco ^{[1
]}

De Michele, Giuseppe ^{[1
]}

Santorelli, Filippo Maria ^{[3
]}

Filla, Alessandro ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Naples, Italy

[2] Univ Naples Federico II, Dept Publ Hlth, Via Pansini 5, I-80131 Naples, Italy

[3] IRCCS Fdn Stella Maris, Mol Med, Pisa, Italy

来源：

NEUROLOGICAL SCIENCES | 2018年 / 39卷 / 11期

关键词：

SCA2; Survival; CAG repeats; Ataxia scale; NATURAL-HISTORY; PREVALENCE;

D O I：

10.1007/s10072-018-3504-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

One hundred-eighteen spinocerebellar ataxia type 2 patients from 35 distinct families personally observed between 1973 and 2016 were retrospectively reviewed. The time point of data collection was 1 January 2017. Thirty-one patients were confined to wheelchair. The median time to wheelchair was 21 years (95% CI, 17.5-24.6). Thirty-seven patients were deceased. The median time to death was 25 years (95% CI, 22.9-27.1). CAG repeat number and ataxia score at first visit influenced the time to wheelchair and death.

引用

页码：1857 / 1860

页数：4

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