Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases

被引：69

作者：

Alam, Manzar ^{[1
]}

Ali, Sabeeha ^{[1
]}

Ahmed, Sarfraz ^{[2
]}

Elasbali, Abdelbaset Mohamed ^{[3
]}

Adnan, Mohd ^{[4
]}

Islam, Asimul ^{[1
]}

Hassan, Md Imtaiyaz ^{[1
]}

Yadav, Dharmendra Kumar ^{[5
]}

机构：

[1] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India

[2] Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India

[3] Jouf Univ, Coll Appl Med Sci Qurayyat, Clin Lab Sci, POB 2014, Sakaka, Saudi Arabia

[4] Univ Hail, Coll Sci, Dept Biol, POB 2440, Hail, Saudi Arabia

[5] Gachon Univ Med & Sci, Coll Pharm, Incheon 21924, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 22期

关键词：

ursolic acid; clinical trials; diabetic neuropathy; inflammatory diseases; inhibitors; targeted therapy; NF-KAPPA-B; TRIPLE REUPTAKE INHIBITORS; INDUCED COGNITIVE DEFICITS; SQUAMOUS-CELL CARCINOMA; OXIDATIVE STRESS; OLEANOLIC ACID; HEPATOCELLULAR-CARCINOMA; IN-VITRO; MYCOBACTERIUM-TUBERCULOSIS; PERIPHERAL NEUROPATHY;

D O I：

10.3390/ijms222212162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs treat multiple diseases, including cancer, diabetic neuropathy, and inflammatory diseases. UA inhibits cancer proliferation, metastasis, angiogenesis, and induced cell death, scavenging free radicals and triggering numerous anti- and pro-apoptotic proteins. The biochemistry of UA has been examined broadly based on the literature, with alterations frequently having been prepared on positions C-3 (hydroxyl), C12C13 (double bonds), and C-28 (carboxylic acid), leading to several UA derivatives with increased potency, bioavailability and water solubility. UA could be used as a protective agent to counter neural dysfunction via anti-oxidant and anti-inflammatory effects. It is a potential therapeutic drug implicated in the treatment of cancer and diabetic complications diseases provide novel machinery to the anti-inflammatory properties of UA. The pharmacological efficiency of UA is exhibited by the therapeutic theory of one-drug -> several targets -> one/multiple diseases. Hence, UA shows promising therapeutic potential for cancer and diabetic neuropathy diseases. This review aims to discuss mechanistic insights into promising beneficial effects of UA. We further explained the pharmacological aspects, clinical trials, and potential limitations of UA for the management of cancer and diabetic neuropathy diseases.

引用

页数：23

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